CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030766
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methionine synthase 
Protein Synonyms/Alias
 cDNA FLJ53729, moderately similar to Methionine synthase (EC 2.1.1.13) 
Gene Name
 MTR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
183CSAGVARKAAEEVTLubiquitination[1]
195VTLQTGIKRFVAGALubiquitination[1, 2]
207GALGPTNKTLSVSPSubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 229 AA 
Protein Sequence
MSAGLRAGCH VVLLCRFSLG SFSVPSRDSA SGRACLAARP TPRTGRVPGK KARAPAVAAP 60
SPERGPRALR AFGVRSPPAT RANGRRQKTR ALCGRLAWRW LAWPLAVVTC GEHVFSAAPS 120
AQGGDSTTCH PRSKTCRNPE YLLAGADIIE TNTFSSTSIA QADYGLEHLA YRMNMCSAGV 180
ARKAAEEVTL QTGIKRFVAG ALGPTNKTLS VSPSVERPDY RNINLPVGS 229 
Gene Ontology
 GO:0008898; F:homocysteine S-methyltransferase activity; IEA:InterPro. 
Interpro
 IPR003726; S_MeTrfase. 
Pfam
 PF02574; S-methyl_trans 
SMART
  
PROSITE
 PS50970; HCY 
PRINTS