CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014771
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Threonine--tRNA ligase, mitochondrial 
Protein Synonyms/Alias
 Threonyl-tRNA synthetase; ThrRS; Threonyl-tRNA synthetase-like 1 
Gene Name
 Tars2 
Gene Synonyms/Alias
 Tarsl1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
215GQLRQLFKDNHFKLHacetylation[1]
288VSGISFPKAELLRNWacetylation[1]
365TPTLFSTKLWEQSGHacetylation[1]
384RAHMFSLKPPGTDGVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 MOD_RES 57 57 Phosphoserine (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 723 AA 
Protein Sequence
MGLCLRWRRL GFPLPGFRRC ELHTVREAPI PTPPHWLAER FGLFEELWTA QVKRLASMTQ 60
KKARTIKISL PEGQKVDAVA WNTTPYQLAQ QISSTLADTA VAAEVNGELY DLDRPLETDC 120
HLRFLTFDSP EGKAVFWRSS AHVLGAAAEQ HLGAVLCRGP STESGFYLDF FLGKERTVRS 180
TELPTLERIC QEIITAAQPF RRLEASRGQL RQLFKDNHFK LHVIEEKVTG TTATVYGCGM 240
SVDLCQGPHL RHTGQIGALK LLTNSSALWR SSEAPETLQR VSGISFPKAE LLRNWEARRE 300
EAELRDHRRI GKEQELFFFH ELSPGSCFFL PRGTRIYNAL VAFIRAEYAR RGFSEVKTPT 360
LFSTKLWEQS GHWEHYRAHM FSLKPPGTDG VDSSQSGHPA RCPKDTLALK PMNCPAHCLM 420
FAHRPRSWRE LPVRLADFGV LHRAEASGSL GGLTRLWRFQ QDDAHIFCAP SQLEAEIRGC 480
LDFLRSVYSV LGFSFHLALS TRPPGFLGEP HLWDQAEKVL QQALEEFGEP WNLNPGDGAF 540
YGPKIDVHLH DALGRPHQCG TIQLDFQLPL RFDLQYKGPA GAPECPVLIH RAVLGSVERL 600
LGVLAESCGG RWPLWLSPFQ VVVIPVRTEQ EDYARQVQQC LQAAGLVSDL DADCGLTLSR 660
RVRRAQLAHY NFQFVVGQRE QSQMSVNVRT RDNRQLGERG LAESVQRLLE LQDARVPNAE 720
ELF 723 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004829; F:threonine-tRNA ligase activity; IEA:EC.
 GO:0006435; P:threonyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR012675; Beta-grasp_dom.
 IPR004095; TGS.
 IPR012676; TGS-like.
 IPR002320; Thr-tRNA-ligase_IIa.
 IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
 IPR012947; tRNA_SAD. 
Pfam
 PF03129; HGTP_anticodon
 PF02824; TGS
 PF00587; tRNA-synt_2b
 PF07973; tRNA_SAD 
SMART
 SM00863; tRNA_SAD 
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR01047; TRNASYNTHTHR.