| Tag | Content |
|---|
| CPLM ID | CPLM-021435 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transmembrane protein 231 |
Protein Synonyms/Alias | |
Gene Name | TMEM231 |
Gene Synonyms/Alias | UNQ870/PRO1886 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 210 | GDLRLQQKQPLSCGG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). |
Sequence Annotation | CARBOHYD 194 194 N-linked (GlcNAc...) (Potential).
CARBOHYD 199 199 N-linked (GlcNAc...) (Potential).
CARBOHYD 221 221 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Complete proteome; Disease mutation; Glycoprotein; Joubert syndrome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 316 AA |
Protein Sequence | MSSSLTRSSA VTARGSAPKP RCSCCWPLRS RTSRRCWWPS GATVSLPRPL CHEAPRARSA 60
RAGLPNRLPT ALFNSGFWLK RSSYEEQPTV RFQHQVLLVA LLGPESDGFL AWSTFPAFNR 120
LQGDRLRVPL VSTREEDRNQ DGKTDMLHFK LELPLQSTEH VLGVQLILTF SYRLHRMATL 180
VMQSMAFLQS SFPVPGSQLY VNGDLRLQQK QPLSCGGLDA RYNISVINGT SPFAYDYDLT 240
HIVAAYQERN VTTVLNDPNP IWLVGRAADA PFVINAIIRY PVEVISYQPG FWEMVKFAWV 300
QYVSILLIFL WVFERIKIFV FQNQVVTTIP VTVTPRGDLC KEHLS 345 |
Gene Ontology | GO:0060170; C:cilium membrane; ISS:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB. GO:0042384; P:cilium assembly; ISS:UniProtKB. GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |