CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012077
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 C-Jun-amino-terminal kinase-interacting protein 2 
Protein Synonyms/Alias
 JIP-2; JNK-interacting protein 2; Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2 
Gene Name
 MAPK8IP2 
Gene Synonyms/Alias
 IB2; JIP2; PRKM8IPL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
575PDLTFSKKFLNVFVNubiquitination[1, 2]
668HAVPGPAKDLLGSKRubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). 
Sequence Annotation
 DOMAIN 604 665 SH3.
 DOMAIN 677 813 PID.
 REGION 110 275 JNK-binding domain (JBD).
 REGION 239 498 Necessary for interaction with FGF13.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Polymorphism; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 824 AA 
Protein Sequence
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY DSDHCEKDSL 60
SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEDEEEEEE EEEGDGEGQE GGDPGSEAPA 120
PGPLIPSPSV EEPHKHRPTT LRLTTLGAQD SLNNNGGFDL VRPASWQETA LCSPAPEALR 180
ELPGPLPATD TGPGGAQSPV RPGCDCEGNR PAEPPAPGGT SPSSDPGIEA DLRSRSSGGR 240
GGRRSSQELS SPGSDSEDAG GARLGRMISS ISETELELSS DGGSSSSGRS SHLTNSIEEA 300
SSPASEPEPP REPPRRPAFL PVGPDDTNSE YESGSESEPD LSEDADSPWL LSNLVSRMIS 360
EGSSPIRCPG QCLSPAPRPP GEPVSPAGGA AQDSQDPEAA AGPGGVELVD METLCAPPPP 420
APAAPRPGPA QPGPCLFLSN PTRDTITPLW AAPGRAARPG RACSAACSEE EDEEDDEEEE 480
DAEDSAGSPG GRGTGPSAPR DASLVYDAVK YTLVVDEHTQ LELVSLRRCA GLGHDSEEDS 540
GGEASEEEAG AALLGGGQVS GDTSPDSPDL TFSKKFLNVF VNSTSRSSST ESFGLFSCLV 600
NGEEREQTHR AVFRFIPRHP DELELDVDDP VLVEAEEDDF WFRGFNMRTG ERGVFPAFYA 660
HAVPGPAKDL LGSKRSPCWV ERFDVQFLGS VEVPCHQGNG ILCAAMQKIA TARKLTVHLR 720
PPASCDLEIS LRGVKLSLSG GGPEFQRCSH FFQMKNISFC GCHPRNSCYF GFITKHPLLS 780
RFACHVFVSQ ESMRPVAQSV GRAFLEYYQE HLAYACPTED IYLE 824 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0014069; C:postsynaptic density; ISS:BHF-UCL.
 GO:0001540; F:beta-amyloid binding; NAS:UniProtKB.
 GO:0019894; F:kinesin binding; ISS:UniProtKB.
 GO:0005078; F:MAP-kinase scaffold activity; NAS:UniProtKB.
 GO:0030295; F:protein kinase activator activity; IDA:MGI.
 GO:0001662; P:behavioral fear response; ISS:BHF-UCL.
 GO:0048813; P:dendrite morphogenesis; ISS:BHF-UCL.
 GO:0000165; P:MAPK cascade; IDA:MGI.
 GO:0046958; P:nonassociative learning; ISS:BHF-UCL.
 GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:BHF-UCL.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.
 GO:0046328; P:regulation of JNK cascade; IDA:UniProtKB.
 GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:BHF-UCL.
 GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL.
 GO:0007172; P:signal complex assembly; TAS:ProtInc.
 GO:0035176; P:social behavior; ISS:BHF-UCL. 
Interpro
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom.
 IPR001452; SH3_domain. 
Pfam
 PF00640; PID
 PF00018; SH3_1 
SMART
 SM00462; PTB
 SM00326; SH3 
PROSITE
 PS01179; PID
 PS50002; SH3 
PRINTS