CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034149
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cadherin-2 
Protein Synonyms/Alias
  
Gene Name
 Cdh2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
699RDKERQAKQLLIDPEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cadherins are calcium dependent cell adhesion proteins (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Cell adhesion; Cell membrane; Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 849 AA 
Protein Sequence
MKFSNCNRKR KVQYESSEPA DFKVDEDGTV YAVRSFPLTA EQAKFLIYAQ DKETQEKWQV 60
AVNLSREPTL TEEPMKEPHE IEEIVFPRQL AKHSGALQRQ KRDWVIPPIN LPENSRGPFP 120
QELVRIRSDR DKNLSLRYSV TGPGADQPPT GIFIINPISG QLSVTKPLDR ELIARFHLRA 180
HAVDINGNQV ENPIDIVINV IDMNDNRPEF LHQVWNGSVP EGSKPGTYVM TVTAIDADDP 240
NALNGMLRYR ILSQAPSTPS PNMFTINNET GDIITVAAGL DREKVQQYTL IIQATDMEGN 300
PTYGLSNTAT AVITVTDVND NPPEFTAMTF YGEVPENRVD VIVANLTVTD KDQPHTPAWN 360
AAYRISGGDP TGRFAILTDP NSNDGLVTVV KPIDFETNRM FVLTVAAENQ VPLAKGIQHP 420
PQSTATVSVT VIDVNENPYF APNPKIIRQE EGLHAGTMLT TLTAQDPDRY MQQNIRYTKL 480
SDPANWLKID PVNGQITTIA VLDRESPNVK NNIYNATFLA SDNGIPPMSG TGTLQIYLLD 540
INDNAPQVLP QEAETCETPE PNSINITALD YDIDPNAGPF AFDLPLSPVT IKRNWTINRL 600
NGDFAQLNLK IKFLEAGIYE VPIIITDSGN PPKSNISILR VKVCQCDSNG DCTDVDRIVG 660
AGLGTGAIIA ILLCIIILLI LVLMFVVWMK RRDKERQAKQ LLIDPEDDVR DNILKYDEEG 720
GGEEDQDYDL SQLQQPDTVE PDAIKPVGIR RLDERPIHAE PQYPVRSAAP HPGDIGDFIN 780
EGLKAADNDP TAPPYDSLLV FDYEGSGSTA GSLSSLNSSS SGGDQDYDYL NDWGPRFKKL 840
ADMYGGGDD 849 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005916; C:fascia adherens; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
 GO:0016339; P:calcium-dependent cell-cell adhesion; IDA:MGI.
 GO:0016477; P:cell migration; IDA:MGI.
 GO:0007157; P:heterophilic cell-cell adhesion; IDA:MGI.
 GO:0007156; P:homophilic cell adhesion; IDA:MGI.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IGI:MGI.
 GO:0043410; P:positive regulation of MAPK cascade; IGI:MGI.
 GO:0051146; P:striated muscle cell differentiation; IGI:MGI. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR009124; Cadherin/Desmocollin.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR014868; Cadherin_pro_dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C
 PF08758; Cadherin_pro 
SMART
 SM00112; CA
 SM01055; Cadherin_pro 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.
 PR01820; DESMOCOLLIN.