UniProt Accession

 HCH1_YEAST; P53834; D6W0R3 

Genbank Protein ID

 Z71557; BK006947 

Genbank Nucleotide ID

 CAA96193.1; DAA10279.1 

Protein Name

 Hsp90 co-chaperone HCH1 

Protein Synonyms/Alias

 High-copy Hsp90 suppressor protein 1 

Gene Name

 HCH1 

Gene Synonyms/Alias

 YNL281W; N0589 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
21	KNTLPWSKDYLNGKL	acetylation	[1]
145	KYQDDLIKEHSKDIQ	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting. 

Sequence Annotation

  

Keyword

 Chaperone; Complete proteome; Cytoplasm; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0001671; F:ATPase activator activity; IDA:SGD.
 GO:0051087; F:chaperone binding; IDA:SGD.
 GO:0006457; P:protein folding; IMP:SGD. 

Interpro

 IPR015310; AHSA1_N. 

Pfam

 PF09229; Aha1_N 

SMART

 SM01000; Aha1_N 

PROSITE

  

PRINTS