UniProt Accession

 OGFD2_HUMAN; Q6N063; B3KT24; Q4KN13; Q6N023; Q9H8K6 

Genbank Protein ID

 AK023553; AK094820; CR457316; BX640675; BX640734; CH471054; BC098119; BC098293; BC101940; BC105637 

Genbank Nucleotide ID

 BAB14610.1; BAG52936.1; CAG33597.1; CAE45807.1; CAE45849.1; EAW98364.1; AAH98119.1; AAH98293.1; AAI01941.1; AAI05638.1 

Protein Name

 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 

Protein Synonyms/Alias

  

Gene Name

 OGFOD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
137	LETVSEEKRIYRVPV	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 DOMAIN 215 309 Fe2OG dioxygenase.
 METAL 235 235 Iron (By similarity).
 METAL 237 237 Iron (By similarity).
 METAL 290 290 Iron (By similarity).
 BINDING 300 300 2-oxoglutarate (Potential).  

Keyword

 Alternative splicing; Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome; Vitamin C. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 350 AA 

Protein Sequence

Gene Ontology

 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
 GO:0016706; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; IEA:InterPro.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. 

Interpro

 IPR005123; Oxoglu/Fe-dep_dioxygenase.
 IPR006620; Pro_4_hyd_alph. 

Pfam

  

SMART

 SM00702; P4Hc 

PROSITE

 PS51471; FE2OG_OXY 

PRINTS