CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006343
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dolichyl-phosphate-mannose--protein mannosyltransferase 1 
Protein Synonyms/Alias
  
Gene Name
 PMT1 
Gene Synonyms/Alias
 YDL095W; D2390 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
414RLHSHDHKPPVSESSacetylation[1]
536KPASFISKFIESHKKacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Seems to be active on chitinase. 
Sequence Annotation
 DOMAIN 324 378 MIR 1.
 DOMAIN 388 448 MIR 2.
 DOMAIN 459 514 MIR 3.
 CARBOHYD 390 390 N-linked (GlcNAc...) (Potential).
 CARBOHYD 513 513 N-linked (GlcNAc...) (Potential).
 CARBOHYD 743 743 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 817 AA 
Protein Sequence
MSEEKTYKRV EQDDPVPELD IKQGPVRPFI VTDPSAELAS LRTMVTLKEK LLVACLAVFT 60
AVIRLHGLAW PDSVVFDEVH FGGFASQYIR GTYFMDVHPP LAKMLYAGVA SLGGFQGDFD 120
FENIGDSFPS TTPYVLMRFF SASLGALTVI LMYMTLRYSG VRMWVALMSA ICFAVENSYV 180
TISRYILLDA PLMFFIAAAV YSFKKYEMYP ANSLNAYKSL LATGIALGMA SSSKWVGLFT 240
VTWVGLLCIW RLWFMIGDLT KSSKSIFKVA FAKLAFLLGV PFALYLVFFY IHFQSLTLDG 300
DGASFFSPEF RSTLKNNKIP QNVVADVGIG SIISLRHLST MGGYLHSHSH NYPAGSEQQQ 360
STLYPHMDAN NDWLLELYNA PGESLTTFQN LTDGTKVRLF HTVTRCRLHS HDHKPPVSES 420
SDWQKEVSCY GYSGFDGDAN DDWVVEIDKK NSAPGVAQER VIALDTKFRL RHAMTGCYLF 480
SHEVKLPAWG FEQQEVTCAS SGRHDLTLWY VENNSNPLLP EDTKRISYKP ASFISKFIES 540
HKKMWHINKN LVEPHVYESQ PTSWPFLLRG ISYWGENNRN VYLLGNAIVW WAVTAFIGIF 600
GLIVITELFS WQLGKPILKD SKVVNFHVQV IHYLLGFAVH YAPSFLMQRQ MFLHHYLPAY 660
YFGILALGHA LDIIVSYVFR SKRQMGYAVV ITFLAASVYF FKSFSPIIYG TPWTQELCQK 720
SQWLSGWDYN CNTYFSSLEE YKNQTLTKRE SQPAATSTVE EITIEGDGPS YEDLMNEDGK 780
KIFKDTEGNE LDPEVVKKML EEEGANILKV EKRAVLE 817 
Gene Ontology
 GO:0031502; C:dolichyl-phosphate-mannose-protein mannosyltransferase complex; IPI:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IDA:SGD.
 GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:SGD.
 GO:0032527; P:protein exit from endoplasmic reticulum; IGI:SGD.
 GO:0035269; P:protein O-linked mannosylation; IMP:SGD.
 GO:1900101; P:regulation of endoplasmic reticulum unfolded protein response; IGI:SGD. 
Interpro
 IPR027005; GlyclTrfase_39_like.
 IPR003342; Glyco_trans_39.
 IPR016093; MIR_motif.
 IPR027004; PMT1. 
Pfam
 PF02815; MIR
 PF02366; PMT 
SMART
 SM00472; MIR 
PROSITE
 PS50919; MIR 
PRINTS