| Tag | Content |
|---|
| CPLM ID | CPLM-006318 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | pH-response transcription factor pacC/RIM101 |
Protein Synonyms/Alias | Regulator of IME2 protein 1; pH-response regulator protein RIM101 |
Gene Name | RIM101 |
Gene Synonyms/Alias | RIM1; YHL027W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 449 | YVPVRLAKYPTGPSL | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes. Required for meiosis, sporulation and invasive growth. |
Sequence Annotation | ZN_FING 146 171 C2H2-type 1.
ZN_FING 182 206 C2H2-type 2.
ZN_FING 212 234 C2H2-type 3.
MOTIF 228 234 Nuclear localization signal (By
MOTIF 450 453 YPX[LI] motif 1.
MOTIF 620 623 YPX[LI] motif 2. |
Keyword | Activator; Complete proteome; Cytoplasm; DNA-binding; Meiosis; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 625 AA |
Protein Sequence | MVPLEDLLNK ENGTAAPQHS RESIVENGTD VSNVTKKDGL PSPNLSKRSS DCSKRPRIRC 60
TTEAIGLNGQ EDERMSPGST SSSCLPYHST SHLNTPPYDL LGASAVSPTT SSSSDSSSSS 120
PLAQAHNPAG DDDDADNDGD SEDITLYCKW DNCGMIFNQP ELLYNHLCHD HVGRKSHKNL 180
QLNCHWGDCT TKTEKRDHIT SHLRVHVPLK PFGCSTCSKK FKRPQDLKKH LKIHLESGGI 240
LKRKRGPKWG SKRTSKKNKS CASDAVSSCS ASVPSAIAGS FKSHSTSPQI LPPLPVGISQ 300
HLPSQQQQRA ISLNQLCSDE LSQYKPVYSP QLSARLQTIL PPLYYNNGST VSQGANSRSM 360
NVYEDGCSNK TIANATQFFT KLSRNMTNNY ILQQSGGSTE SSSSSGRIPV AQTSYVQPPN 420
APSYQSVQGG SSISATANTA TYVPVRLAKY PTGPSLTEHL PPLHSNTAGG VFNRQSQYAM 480
PHYPSVRAAP SYSSSGCSIL PPLQSKIPML PSRRTMAGGT SLKPNWEFSL NQKSCTNDII 540
MSKLAIEEVD DESEIEDDFV EMLGIVNIIK DYLLCCVMED LDDEESEDKD EENAFLQESL 600
EKLSLQNQMG TNSVRILTKY PKILV 625 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:SGD. GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IMP:SGD. GO:0043565; F:sequence-specific DNA binding; IDA:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0030437; P:ascospore formation; IMP:SGD. GO:0000917; P:barrier septum assembly; IGI:SGD. GO:0071469; P:cellular response to alkalinity; IMP:SGD. GO:0071454; P:cellular response to anoxia; IMP:SGD. GO:0009272; P:fungal-type cell wall biogenesis; IMP:SGD. GO:0007126; P:meiosis; IMP:SGD. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |