UniProt Accession

 PPIE_MOUSE; Q9QZH3; Q9D8C0 

Genbank Protein ID

 AK008177; BC045154; AF182825 

Genbank Nucleotide ID

 BAB25512.1; AAH45154.1; AAF01030.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase E 

Protein Synonyms/Alias

 PPIase E; Cyclophilin E; Cyclophilin-33; Rotamase E 

Gene Name

 Ppie 

Gene Synonyms/Alias

 Cyp33 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
218	GKSIYGKKFDDENFI	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in pre-mRNA splicing (By similarity). 

Sequence Annotation

 DOMAIN 5 83 RRM.
 DOMAIN 143 299 PPIase cyclophilin-type.  

Keyword

 Complete proteome; Isomerase; mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding; Rotamase; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS.
 IPR016304; Cyclophilin-type_PPIase_E.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00160; Pro_isomerase
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2
 PS50102; RRM 

PRINTS

 PR00153; CSAPPISMRASE.