CPLM-004536

Genbank Nucleotide ID

High mobility group protein HMG-I/HMG-Y

Protein Synonyms/Alias

HMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R

Homo sapiens (Human)

Position	Peptide	Type	References
15	SSQPLASKQEKDGTE	acetylation	[1]
54	RGRPKGSKNKGAAKT	acetylation	[1]
56	RPKGSKNKGAAKTRK	acetylation	[1]
60	SKNKGAAKTRKTTTT	acetylation	[1]
63	KGAAKTRKTTTTPGR	acetylation	[1]

[1] A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins.
Zhang Q, Zhang K, Zou Y, Perna A, Wang Y.
J Am Soc Mass Spectrom. 2007 Sep;18(9):1569-78. [PMID: 17627840]

Functional Description

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

DNA_BIND 21 31 A.T hook 1.
DNA_BIND 53 63 A.T hook 2.
DNA_BIND 78 89 A.T hook 3.
REGION 53 77 Interaction with HIPK2 (By similarity).
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 15 15 N6-acetyllysine.
MOD_RES 26 26 Asymmetric dimethylarginine; in isoform
MOD_RES 26 26 Omega-N-methylarginine; in isoform HMG-I;
MOD_RES 26 26 Symmetric dimethylarginine; in isoform
MOD_RES 36 36 Phosphoserine; by HIPK2 and CDC2; in
MOD_RES 39 39 Phosphothreonine.
MOD_RES 44 44 Phosphoserine.
MOD_RES 49 49 Phosphoserine.
MOD_RES 53 53 Phosphothreonine; by HIPK2 and CDC2; in
MOD_RES 58 58 Asymmetric dimethylarginine; by PRMT6;
MOD_RES 58 58 Omega-N-methylarginine; by PRMT6;
MOD_RES 60 60 Asymmetric dimethylarginine; by PRMT6;
MOD_RES 60 60 Omega-N-methylarginine; by PRMT6;
MOD_RES 78 78 Phosphothreonine; by HIPK2 and CDC2; in
MOD_RES 99 99 Phosphoserine; in isoform HMG-I and
MOD_RES 102 102 Phosphoserine; by CK; in isoform HMG-I
MOD_RES 103 103 Phosphoserine; by CK; in isoform HMG-I

3D-structure; Acetylation; Alternative splicing; Chromosomal rearrangement; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Host-virus interaction; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0035985; C:senescence-associated heterochromatin focus; IDA:UniProtKB.
GO:0005667; C:transcription factor complex; TAS:UniProtKB.
GO:0051575; F:5'-deoxyribose-5-phosphate lyase activity; IDA:UniProtKB.
GO:0003680; F:AT DNA binding; TAS:UniProtKB.
GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IDA:UniProtKB.
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IMP:UniProtKB.
GO:0042975; F:peroxisome proliferator activated receptor binding; IDA:UniProtKB.
GO:0046965; F:retinoid X receptor binding; IDA:UniProtKB.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.
GO:0006284; P:base-excision repair; IDA:UniProtKB.
GO:0006268; P:DNA unwinding involved in replication; NAS:UniProtKB.
GO:0075713; P:establishment of integrated proviral latency; TAS:Reactome.
GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.
GO:0031936; P:negative regulation of chromatin silencing; TAS:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
GO:0006337; P:nucleosome disassembly; TAS:UniProtKB.
GO:0090402; P:oncogene-induced senescence; IDA:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IMP:UniProtKB.
GO:0006461; P:protein complex assembly; TAS:UniProtKB.
GO:0009615; P:response to virus; IEP:UniProtKB.
GO:0035986; P:senescence-associated heterochromatin focus assembly; IDA:UniProtKB.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

IPR020478; AT_hook-like.
IPR017956; AT_hook_DNA-bd_motif.
IPR000116; HMGI/HMGY.
IPR000637; HMGI/Y_DNA-bd_CS.

PR00929; ATHOOK.
PR00930; HIGHMOBLTYIY.