| Tag | Content |
|---|
| CPLM ID | CPLM-004333 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily A member 4 |
Protein Synonyms/Alias | RCK4; RHK1; RK3; Voltage-gated potassium channel subunit Kv1.4 |
Gene Name | Kcna4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 209 | TLLGDPEKRTQYFDP | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
Sequence Annotation | MOTIF 526 531 Selectivity filter (By similarity).
MOTIF 653 655 PDZ-binding.
MOD_RES 123 123 Phosphoserine (By similarity).
MOD_RES 601 601 Phosphoserine; by PKA (Potential).
CARBOHYD 183 183 N-linked (GlcNAc...) (Potential).
CARBOHYD 354 354 N-linked (GlcNAc...) (Potential).
CARBOHYD 644 644 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 655 AA |
Protein Sequence | MEVAMVSAES SGCNSHMPYG YAAQARARER ERLAHSRAAA AAAVAAATAA VEGTGGSGGG 60
PHHHHQTRGA YSSHDPQGSR GSREEEATRT EKKKKLHHRQ SSFPHCSDLM PSGSEEKILR 120
ELSEEEEDEE EEEEEEEEGR FYYSEEDHGD GCSYTDLLPQ DDGGGGGYSS VRYSDCCERV 180
VINVSGLRFE TQMKTLAQFP ETLLGDPEKR TQYFDPLRNE YFFDRNRPSF DAILYYYQSG 240
GRLKRPVNVP FDIFTEEVKF YQLGEEALLK FREDEGFVRE EEDRALPENE FKKQIWLLFE 300
YPESSSPARG IAIVSVLVIL ISIVIFCLET LPEFRDDRDL IMALSAGGHS RLLNDTSAPH 360
LENSGHTIFN DPFFIVETVC IVWFSFEFVV RCFACPSQAL FFKNIMNIID IVSILPYFIT 420
LGTDLAQQQG GGNGQQQQAM SFAILRIIRL VRVFRIFKLS RHSKGLQILG HTLRASMREL 480
GLLIFFLFIG VILFSSAVYF AEADEPTTHF QSIPDAFWWA VVTMTTVGYG DMKPITVGGK 540
IVGSLCAIAG VLTIALPVPV IVSNFNYFYH RETENEEQTQ LTQNAVSCPY LPSNLLKKFR 600
SSTSSSLGDK SEYLEMEEGV KESLCGKEEK CQGKGDDSET DKNNCSNAKA VETDV 655 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:RGD. GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. GO:0030955; F:potassium ion binding; IEA:InterPro. GO:0005249; F:voltage-gated potassium channel activity; IDA:RGD. GO:0051260; P:protein homooligomerization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |