| Tag | Content |
|---|
| CPLM ID | CPLM-015904 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Autophagy-related protein 9A |
Protein Synonyms/Alias | APG9-like 1; mATG9 |
Gene Name | ATG9A |
Gene Synonyms/Alias | APG9L1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 164 | YMVALVNKSLLPLRF | ubiquitination | [1] | | 520 | TAFLGFLKEQVQRDG | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. |
Sequence Annotation | MOD_RES 18 18 Phosphoserine.
MOD_RES 656 656 Phosphoserine.
MOD_RES 735 735 Phosphoserine.
MOD_RES 738 738 Phosphoserine.
MOD_RES 741 741 Phosphoserine.
MOD_RES 828 828 Phosphoserine.
CARBOHYD 99 99 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Autophagy; Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 839 AA |
Protein Sequence | MLIGEIFELM QFLFVVAFTT FLVSCVDYDI LFANKMVNHS LHPTEPVKVT LPDAFLPAQV 60
CSARIQENGS LITILVIAGV FWIHRLIKFI YNICCYWEIH SFYLHALRIP MSALPYCTWQ 120
EVQARIVQTQ KEHQICIHKR ELTELDIYHR ILRFQNYMVA LVNKSLLPLR FRLPGLGEAV 180
FFTRGLKYNF ELILFWGPGS LFLNEWSLKA EYKRGGQRLE LAQRLSNRIL WIGIANFLLC 240
PLILIWQILY AFFSYAEVLK REPGALGARC WSLYGRCYLR HFNELEHELQ SRLNRGYKPA 300
SKYMNCFLSP LLTLLAKNGA FFAGSILAVL IALTIYDEDV LAVEHVLTTV TLLGVTVTVC 360
RSFIPDQHMV FCPEQLLRVI LAHIHYMPDH WQGNAHRSQT RDEFAQLFQY KAVFILEELL 420
SPIVTPLILI FCLRPRALEI IDFFRNFTVE VVGVGDTCSF AQMDVRQHGH PQWLSAGQTE 480
ASVYQQAEDG KTELSLMHFA ITNPGWQPPR ESTAFLGFLK EQVQRDGAAA SLAQGGLLPE 540
NALFTSIQSL QSESEPLSLI ANVVAGSSCR GPPLPRDLQG SRHRAEVASA LRSFSPLQPG 600
QAPTGRAHST MTGSGVDART ASSGSSVWEG QLQSLVLSEY ASTEMSLHAL YMHQLHKQQA 660
QAEPERHVWH RRESDESGES APDEGGEGAR APQSIPRSAS YPCAAPRPGA PETTALHGGF 720
QRRYGGITDP GTVPRVPSHF SRLPLGGWAE DGQSASRHPE PVPEEGSEDE LPPQVHKV 778 |
Gene Ontology | GO:0000421; C:autophagic vacuole membrane; IEA:UniProtKB-SubCell. GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. GO:0000045; P:autophagic vacuole assembly; IMP:MGI. GO:0045087; P:innate immune response; IEA:Compara. GO:0034067; P:protein localization to Golgi apparatus; IEA:Compara. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
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PRINTS | |