| Tag | Content |
|---|
| CPLM ID | CPLM-011499 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase BRE1 |
Protein Synonyms/Alias | Brefeldin A-sensitivity protein 1 |
Gene Name | BRE1 |
Gene Synonyms/Alias | YDL074C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 11 | EPATKKIKLELSDPS | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis. |
Sequence Annotation | ZN_FING 648 687 RING-type. |
Keyword | Chromatin regulator; Coiled coil; Complete proteome; Ligase; Metal-binding; Nucleus; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 700 AA |
Protein Sequence | MTAEPATKKI KLELSDPSEP LTQSDVIAFQ KEALFRCINR RRVDFEALRK QYELSRRECI 60
DVSRKLANIM ALIVTLARFI ETFCTDANEK QLCREIAQGD ETLIVQRSDS FMKLLTKYGK 120
PNTTDSNTNS NASDHIQELT TELKNLRKSK EELFYENSQL TEEISALKEY YTNIIRKYDR 180
DESFTIKRVF KEDKTDAVKE LREDEKESNE NNIKSGNKDS SAINGDNTSK KSEKGDELVQ 240
AEDERKEDAE NEKLELDLKF SDLRAEINSL SSTIKDLENI RRENEEELIK TRSEVSNLKK 300
QQIAAADQDP DFKSYDHESL LAKIQHLTEQ NAELSEINSS FLSKFQVLAK EKEIYTKKVR 360
EEFQKSLDSL VEMNSSLEKD VVRIRTARDD LLSKIAILEA EKSKTEVLSD LQHAIDILKE 420
QWTKIDQRSN DTKSSSTQDA LIKEIQDLEK GFRELSDLTH KKYSEIINHE SVISKLTVEK 480
TKADQKYFAA MRSKDSILIE IKTLSKSLSK SNELILQLKD SDRLLQQKIG NLHKQLDLSQ 540
NNERRLIDSS KTETLKIIDL NNTSTKLKRS LEKLQEESNK SIADMTHLET KLNDTEIELK 600
HFKQKASHLE SKCEKLHDTL FRGNNKNKGS SDEALVEELA NFRTLVYCSL CSKNWKNMAI 660
KTCGHVFCEN CCKERLAARM RKCPTCNKAF SSNDLLTVHL 700 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004842; F:ubiquitin-protein ligase activity; IMP:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006348; P:chromatin silencing at telomere; IMP:SGD. GO:0000724; P:double-strand break repair via homologous recombination; IGI:SGD. GO:0010390; P:histone monoubiquitination; IMP:SGD. GO:0031573; P:intra-S DNA damage checkpoint; IMP:SGD. GO:0042138; P:meiotic DNA double-strand break formation; IMP:SGD. GO:0031571; P:mitotic G1 DNA damage checkpoint; IMP:SGD. GO:0006366; P:transcription from RNA polymerase II promoter; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |