CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003937
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein G(t) subunit alpha-1 
Protein Synonyms/Alias
 Transducin alpha-1 chain 
Gene Name
 GNAT1 
Gene Synonyms/Alias
 GNATR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18HSRELEKKLKEDAEKacetylation[1]
25KLKEDAEKDARTVKLacetylation[1]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 
Functional Description
 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. 
Sequence Annotation
 NP_BIND 36 43 GTP (By similarity).
 NP_BIND 171 177 GTP (By similarity).
 NP_BIND 196 200 GTP (By similarity).
 NP_BIND 265 268 GTP (By similarity).
 METAL 43 43 Magnesium (By similarity).
 METAL 177 177 Magnesium (By similarity).
 BINDING 322 322 GTP; via amide nitrogen (By similarity).
 MOD_RES 142 142 Phosphotyrosine; by SRC.
 MOD_RES 174 174 ADP-ribosylarginine; by cholera toxin (By
 MOD_RES 347 347 ADP-ribosylcysteine; by pertussis toxin
 LIPID 2 2 N-myristoyl glycine.  
Keyword
 3D-structure; ADP-ribosylation; Complete proteome; Congenital stationary night blindness; Disease mutation; GTP-binding; Lipoprotein; Magnesium; Metal-binding; Myristate; Nucleotide-binding; Phosphoprotein; Reference proteome; Sensory transduction; Transducer; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 350 AA 
Protein Sequence
MGAGASAEEK HSRELEKKLK EDAEKDARTV KLLLLGAGES GKSTIVKQMK IIHQDGYSLE 60
ECLEFIAIIY GNTLQSILAI VRAMTTLNIQ YGDSARQDDA RKLMHMADTI EEGTMPKEMS 120
DIIQRLWKDS GIQACFERAS EYQLNDSAGY YLSDLERLVT PGYVPTEQDV LRSRVKTTGI 180
IETQFSFKDL NFRMFDVGGQ RSERKKWIHC FEGVTCIIFI AALSAYDMVL VEDDEVNRMH 240
ESLHLFNSIC NHRYFATTSI VLFLNKKDVF FEKIKKAHLS ICFPDYDGPN TYEDAGNYIK 300
VQFLELNMRR DVKEIYSHMT CATDTQNVKF VFDAVTDIII KENLKDCGLF 350 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0032391; C:photoreceptor connecting cilium; IEA:Compara.
 GO:0001917; C:photoreceptor inner segment; IDA:UniProtKB.
 GO:0042622; C:photoreceptor outer segment membrane; ISS:UniProtKB.
 GO:0000035; F:acyl binding; ISS:UniProtKB.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019901; F:protein kinase binding; ISS:UniProtKB.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0071257; P:cellular response to electrical stimulus; IEA:Compara.
 GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:RefGenome.
 GO:0050908; P:detection of light stimulus involved in visual perception; IMP:UniProtKB.
 GO:0042462; P:eye photoreceptor cell development; IEA:Compara.
 GO:0051344; P:negative regulation of cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.
 GO:0007603; P:phototransduction, visible light; IMP:UniProtKB.
 GO:0051343; P:positive regulation of cyclic-nucleotide phosphodiesterase activity; IEA:Compara.
 GO:0009642; P:response to light intensity; IEA:Compara.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0016056; P:rhodopsin mediated signaling pathway; IEA:Compara.
 GO:0050917; P:sensory perception of umami taste; IBA:RefGenome. 
Interpro
 IPR001408; Gprotein_alpha_I.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00503; G-alpha 
SMART
 SM00275; G_alpha 
PROSITE
  
PRINTS
 PR00318; GPROTEINA.
 PR00441; GPROTEINAI.