CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012854
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PWWP domain-containing protein MUM1 
Protein Synonyms/Alias
 Mutated melanoma-associated antigen 1; MUM-1; Protein expandere 
Gene Name
 MUM1 
Gene Synonyms/Alias
 EXPAND1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MADAKYVLCRWEubiquitination[1]
19EKRLWPAKVLARTATubiquitination[1]
122ADRSLRGKPMEHVSSubiquitination[1]
453GHMNPKMKGFTVSLKubiquitination[1]
470KHFDCKEKQTLLNQAubiquitination[1]
538TKLPQLSKGSPEEPVubiquitination[1]
581KLVEYIVKAKGAESHubiquitination[1]
642VYQEVGAKVLQRTNGubiquitination[1, 2]
685TAEEKYIKGPSLSYRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. 
Sequence Annotation
 DOMAIN 411 472 PWWP.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; DNA damage; DNA repair; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 710 AA 
Protein Sequence
MADAKYVLCR WEKRLWPAKV LARTATSTKN KRRKEYFLAV QILSLEEKIK VKSTEVEILE 60
KSQIEAIASS LASQNEVPAA PLEELAYRRS LRVALDVLSE GSIWSQESSA GTGRADRSLR 120
GKPMEHVSSP CDSNSSSLPR GDVLGSSRPH RRRPCVQQSL SSSFTCEKDP ECKVDHKKGL 180
RKSENPRGPL VLPAGGGAQD ESGSRIHHKN WTLASKRGGN SAQKASLCLN GSSLSEDDTE 240
RDMGSKGGSW AAPSLPSGVR EDDPCANAEG HDPGLPLGSL TAPPAPEPSA CSEPGECPAK 300
KRPRLDGSQR PPAVQLEPMA AGAAPSPGPG PGPRESVTPR STARLGPPPS HASADATRCL 360
PCPDSQKLEK ECQSSEESMG SNSMRSILEE DEEDEEPPRV LLYHEPRSFE VGMLVWHKHK 420
KYPFWPAVVK SVRQRDKKAS VLYIEGHMNP KMKGFTVSLK SLKHFDCKEK QTLLNQARED 480
FNQDIGWCVS LITDYRVRLG CGSFAGSFLE YYAADISYPV RKSIQQDVLG TKLPQLSKGS 540
PEEPVVGCPL GQRQPCRKML PDRSRAARDR ANQKLVEYIV KAKGAESHLR AILKSRKPSR 600
WLQTFLSSSQ YVTCVETYLE DEGQLDLVVK YLQGVYQEVG AKVLQRTNGD RIRFILDVLL 660
PEAIICAISA VDEVDYKTAE EKYIKGPSLS YREKEIFDNQ LLEERNRRRR 710 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0031491; F:nucleosome binding; IDA:UniProtKB.
 GO:0006325; P:chromatin organization; IMP:UniProtKB.
 GO:0006281; P:DNA repair; IMP:UniProtKB. 
Interpro
 IPR000313; PWWP. 
Pfam
 PF00855; PWWP 
SMART
  
PROSITE
 PS50812; PWWP 
PRINTS