UniProt Accession

 NAA50_MOUSE; Q6PGB6; Q3TH79; Q3TK59; Q7TML2; Q80VE3; Q9D0Q8 

Genbank Protein ID

 AK011160; AK135658; AK145345; AK156791; AK167141; AK168394; BC046283; BC055846; BC057117 

Genbank Nucleotide ID

 BAB27439.1; BAE22602.1; BAE26378.1; BAE33858.1; BAE39286.1; BAE40319.1; AAH46283.1; AAH55846.1; AAH57117.1 

Protein Name

 N-alpha-acetyltransferase 50 

Protein Synonyms/Alias

 N-acetyltransferase NAT13; NatE catalytic subunit 

Gene Name

 Naa50 

Gene Synonyms/Alias

 Mak3; Nat13 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	DVTPHNIKQLKRLNQ	ubiquitination	[1]
34	FPVSYNDKFYKDVLE	acetylation	[2, 3, 4, 5, 6]
34	FPVSYNDKFYKDVLE	ubiquitination	[1]
37	SYNDKFYKDVLEVGE	acetylation	[2, 3, 5, 6]
37	SYNDKFYKDVLEVGE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity (By similarity). 

Sequence Annotation

 DOMAIN 6 155 N-acetyltransferase.
 REGION 79 90 Coenzyme A binding (By similarity).
 MOD_RES 12 12 Phosphothreonine (By similarity).
 MOD_RES 34 34 N6-acetyllysine (By similarity).
 MOD_RES 37 37 N6-acetyllysine (By similarity).
 MOD_RES 110 110 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:HGNC.
 GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
 GO:0006474; P:N-terminal protein amino acid acetylation; TAS:HGNC. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS