| Tag | Content |
|---|
| CPLM ID | CPLM-003230 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Putative cardiolipin synthase YbhO |
Protein Synonyms/Alias | CL synthase |
Gene Name | ybhO |
Gene Synonyms/Alias | b0789; JW0772 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 26 | QYYPAVFKAIGEAQE | acetylation | [1] | | 144 | SSYGPEAKQDYAVRL | acetylation | [1] | | 214 | DIERHYLKMLTQARR | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate. Catalyzes little, if any, cardiolipin synthesis in vivo, even when the expression level is very high. |
Sequence Annotation | DOMAIN 108 135 PLD phosphodiesterase 1.
DOMAIN 285 312 PLD phosphodiesterase 2.
ACT_SITE 113 113 Potential.
ACT_SITE 290 290 Potential. |
Keyword | Cell membrane; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Repeat; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 413 AA |
Protein Sequence | MKCSWREGNK IQLLENGEQY YPAVFKAIGE AQERIILETF IWFEDDVGKQ LHAALLAAAQ 60
RGVKAEVLLD GYGSPDLSDE FVNELTAAGV VFRYYDPRPR LFGMRTNVFR RMHRKIVVID 120
ARIAFIGGLN YSAEHMSSYG PEAKQDYAVR LEGPIVEDIL QFELENLPGQ SAARRWWRRH 180
HKAEENRQPG EAQVLLVWRD NEEHRDDIER HYLKMLTQAR REVIIANAYF FPGYRFLHAL 240
RKAARRGVRI KLIIQGEPDM PIVRVGARLL YNYLVKGGVQ VFEYRRRPLH GKVALMDDHW 300
ATVGSSNLDP LSLSLNLEAN VIIHDRHFNQ TLRDNLNGII AADCQQVDET MLPKRTWWNL 360
TKSVLAFHFL RHFPALVGWL PAHTPRLAQV DPPAQPTMET QDRVETENTG VKP 413 |
Gene Ontology | GO:0016020; C:membrane; IDA:EcoCyc. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0008808; F:cardiolipin synthase activity; IDA:EcoCyc. GO:0004630; F:phospholipase D activity; IDA:EcoliWiki. GO:0032049; P:cardiolipin biosynthetic process; IMP:EcoCyc. |
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