CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039040
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 
Protein Synonyms/Alias
  
Gene Name
 Hcn2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
120LLQPGVNKFSLRMFGubiquitination[1]
130LRMFGSQKAVEREQEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 833 AA 
Protein Sequence
PPQPQPPPAP PPNPTTPSHP ESADEPGPRS RLCSRDSSCT PGAAKGGANG ECGRGEPQCS 60
PEGPARGPKV SFSCRGAASG PAAAEEAGSE EAGPAGEPRG SQASFLQRQF GALLQPGVNK 120
FSLRMFGSQK AVEREQERVK SAGAWIIHPY SDFRFYWDFT MLLFMVGNLI IIPVGITFFK 180
DETTAPWIVF NVVSDTFFLM DLVLNFRTGI VIEDNTEIIL DPEKIKKKYL RTWFVVDFVS 240
SIPVDYIFLI VEKGIDSEVY KTARALRIVR FTKILSLLRL LRLSRLIRYI HQWEEIFHMT 300
YDLASAVMRI CNLISMMLLL CHWDGCLQFL VPMLQDFPSD CWVSINNMVN HSWSELYSFA 360
LFKAMSHMLC IGYGRQAPES MTDIWLTMLS MIVGATCYAM FIGHATALIQ SLDSSRRQYQ 420
EKYKQVEQYM SFHKLPADFR QKIHDYYEHR YQGKMFDEDS ILGELNGPLR EEIVNFNCRK 480
LVASMPLFAN ADPNFVTAML TKLKFEVFQP GDYIIREGTI GKKMYFIQHG VVSVLTKGNK 540
EMKLSDGSYF GEICLLTRGR RTASVRADTY CRLYSLSVDN FNEVLEEYPM MRRAFETVAI 600
DRLDRIGKKN SILLHKVQHD LSSGVFNNQE NAIIQEIVKY DREMVQQAEL GQRVGLFPPP 660
PPPQVTSAIA TLQQAVAMSF CPQVARPLVG PLALGSPRLV RRAPPGPLPP AASPGPPAAS 720
PPAAPSSPRA PRTSPYGVPG SPATRVGPAL PARRLSRASR PLSASQPSLP HGAPAPSPAA 780
SARPASSSTP RLGPAPTTRT AAPSPDRRDS ASPGAASGLD PLDSARSRLS SNL 833 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
 GO:0042391; P:regulation of membrane potential; IEA:Compara. 
Interpro
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR005821; Ion_trans_dom.
 IPR013621; Ion_trans_N.
 IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding
 PF00520; Ion_trans
 PF08412; Ion_trans_N 
SMART
 SM00100; cNMP 
PROSITE
 PS00888; CNMP_BINDING_1
 PS50042; CNMP_BINDING_3 
PRINTS
 PR01463; EAGCHANLFMLY.