CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014581
UniProt Accession
Genbank Protein ID
 S81393 
Genbank Nucleotide ID
Protein Name
 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase 
Protein Synonyms/Alias
 Aspartylglucosaminidase; AGA; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain 
Gene Name
 Aga 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
183SKYCGPYKPSGFLKQacetylation[1]
288DPAIACQKVILRIQKacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. 
Sequence Annotation
 REGION 234 237 Substrate binding (By similarity).
 REGION 257 260 Substrate binding (By similarity).
 ACT_SITE 206 206 Nucleophile (By similarity).
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
 DISULFID 64 69 By similarity.
 DISULFID 163 179 By similarity.
 DISULFID 286 306 By similarity.
 DISULFID 317 345 By similarity.  
Keyword
 Autocatalytic cleavage; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MERKSNLSLL LLLLVLGMPL VRGSSPLPLV VNTWPFKNAT EAAWWTLLSG GSALDAVENG 60
CAVCEKEQCD GTVGFGGSPD EGGETTLDAM IMDGTAMDVG AVGGLRRIKN AIGVARRVLE 120
HTTHTLLVGD SATKFAESMG FTNEDLSTKT SRDLHSDWLS RNCQPNYWRN VIPDPSKYCG 180
PYKPSGFLKQ SISPHKEEVD IHSHDTIGMV VIHKTGHTAA GTSTNGIKFK IPGRVGDSPI 240
PGAGAYADDT AGAAAATGDG DTLLRFLPSY QAVEYMRGGD DPAIACQKVI LRIQKYYPNF 300
FGAVICASVN GSYGAACNKL PTFTQFSFMV SNSLHNEPTE KKVDCI 346 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0003948; F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; IDA:MGI.
 GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
 GO:0006517; P:protein deglycosylation; IEA:Compara.
 GO:0051604; P:protein maturation; IDA:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR000246; Peptidase_T2. 
Pfam
 PF01112; Asparaginase_2 
SMART
  
PROSITE
  
PRINTS