CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013721
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methylmalonate semialdehyde dehydrogenase [acylating] 2 
Protein Synonyms/Alias
 MMSA dehydrogenase 2; MMSDH 2; MSDH 2; Malonate semialdehyde dehydrogenase [acetylating] 2; MSA dehydrogenase 2 
Gene Name
 iolA2 
Gene Synonyms/Alias
 GK1887 
Created Date
 July 27, 2013 
Organism
 Geobacillus kaustophilus (strain HTA426) 
NCBI Taxa ID
 235909 
Lysine Modification
Position
Peptide
Type
References
9TTGVQTLKNYIGGQWacetylation[1]
55DEAVRAAKEAFKTWRacetylation[1]
59RAAKEAFKTWRKTPVacetylation[1]
97LVTLENGKSYNEAYGacetylation[1]
255VQALTGAKNHSIVMPacetylation[1]
383TTDMTIWKDEIFAPVacetylation[1]
408EAIEVANKSPFANGAacetylation[1]
Reference
 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 
Functional Description
 Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively (By similarity). 
Sequence Annotation
 NP_BIND 177 181 NAD (By similarity).
 ACT_SITE 285 285 Nucleophile (By similarity).
 BINDING 385 385 NAD (By similarity).  
Keyword
 Complete proteome; NAD; Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 484 AA 
Protein Sequence
MTTGVQTLKN YIGGQWVESR SGKTEAVPNP ATGEVLAYVP ISSREELDEA VRAAKEAFKT 60
WRKTPVPRRA RILFKYQQLL VEHWEELARL VTLENGKSYN EAYGEVQRGI ECVEFAAGAP 120
TLMMGRQLPD IATGIESGMY RYPIGVVGGI TPFNFPMMVP CWMFPLAIAC GNTFVLKPSE 180
RTPMLANRLA ELFKEAGLPD GVLNIVHGAH DVVNGLLEHP DVKAISFVGS QPVGEYVYKT 240
AAAHGKRVQA LTGAKNHSIV MPDADLNVAV REIINAAFGS AGERCMAASV VVAVGEIADE 300
LVEKLVAAAN ELKIGNGLEE SVFLGPVIRE AHKQRTVKYI ELGEKEGAIL VRDGRKDAAV 360
QDNGYFIGPT IFDRVTTDMT IWKDEIFAPV LSIVRVETLD EAIEVANKSP FANGACIYTR 420
DGGNVRKFRE EIDAGMLGVN LGVPAPMAFF PFSGWKNSFY GDLHANGMDG VEFYTRKKMM 480
TSRW 484 
Gene Ontology
 GO:0018478; F:malonate-semialdehyde dehydrogenase (acetylating) activity; IEA:HAMAP.
 GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating) activity; IEA:HAMAP.
 GO:0019310; P:inositol catabolic process; IEA:HAMAP. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010061; MeMal-semiAld_DH.
 IPR023510; MeMal-semiAld_DH_GmP_bac. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS