CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021070
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sciellin 
Protein Synonyms/Alias
  
Gene Name
 Scel 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
82LIERDEPKATISRYRacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope (By similarity). 
Sequence Annotation
 REPEAT 207 226 1.
 REPEAT 227 241 2.
 REPEAT 242 261 3.
 REPEAT 262 281 4.
 REPEAT 282 301 5.
 REPEAT 302 320 6.
 REPEAT 321 340 7.
 REPEAT 341 360 8.
 REPEAT 361 380 9.
 REPEAT 381 398 10.
 REPEAT 399 418 11.
 REPEAT 419 438 12.
 REPEAT 439 458 13.
 REPEAT 459 477 14.
 REPEAT 478 496 15.
 DOMAIN 583 649 LIM zinc-binding.
 REGION 207 496 15 X approximate tandem repeats.
 MOD_RES 67 67 Phosphoserine.
 MOD_RES 90 90 Phosphoserine.
 MOD_RES 264 264 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; LIM domain; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 652 AA 
Protein Sequence
MSNFSSRKKS PTGNDLKSAR GAELRQQGFQ DVNKRRAFLQ DNSWIKKPPE EEQDGNYGRV 60
VLNRHNSHDA LDRKLIERDE PKATISRYRS EDMLDRTLSS FRTPQSTKTP AVSSFNANTT 120
ATASTPATTP VKKKRQSWFP PPPPGHNASP STAASRRDPA LHPPLPPKPC SPIASPKPLG 180
RTNRQIHAAT AGACGETERH AERNIRTEDL DDIIRVAAAL QKTDKGEELD NLIRMNKSLN 240
RNQGLDGLFR ANLKAQQLDK RAQSLESLIY MNTQTDRDGK GNQAFGSLKK INQRADPDRR 300
SQDLRSVIRT HATAERIGRR KQDLDGLIKV NPDTNKNMKR GKSLDNLIKV TPEVNRSNKG 360
GPSLDNFTKG VPARSRANQR DQDLDSLIKV TPSANRSSQH SLDELINTSP QTIKTTARHQ 420
DLDKFIKVNP DVLTNNQRNH DVDSTIRGNP TGTRCEQSEE LDNLIKVKPS ALRNTNGGQD 480
LESLTEVNSH VAEKNGRIDG QANGLTNSLF KESTRASVYS YEARNSLSSN SGNKNGGPKD 540
TVVYTRTYVE NSKSPKDGYQ ENISGKYIQT VYSTSDRSVI ERDMCTYCRK PLGVETKMIL 600
DELQICCHST CFKCEICKRP LENLQAGDSI WIYRQTIHCE PCYSKVMAKW IQ 652 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009790; P:embryo development; IDA:UniProtKB.
 GO:0030216; P:keratinocyte differentiation; ISS:UniProtKB. 
Interpro
 IPR001781; Znf_LIM. 
Pfam
  
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS