UniProt Accession

 EBP_HUMAN; Q15125; Q6FGL3; Q6IBI9 

Genbank Protein ID

 Z37986; CR456815; CR542094; AF196969; AF196972; CH471224; BC001549; BC001572; BC046501 

Genbank Nucleotide ID

 CAA86068.1; CAG33096.1; CAG46891.1; EAW50773.1; AAH01549.1; AAH01572.1; AAH46501.1 

Protein Name

 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 

Protein Synonyms/Alias

 Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding protein 

Gene Name

 EBP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
221	AQSTLDAKATKAKSK	acetylation	[1, 2]
221	AQSTLDAKATKAKSK	ubiquitination	[3, 4]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. 

Sequence Annotation

 MOD_RES 2 2 N-acetylthreonine (By similarity).  

Keyword

 Acetylation; Cataract; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Disease mutation; Dwarfism; Endoplasmic reticulum; Ichthyosis; Isomerase; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0000247; F:C-8 sterol isomerase activity; IEA:Compara.
 GO:0047750; F:cholestenol delta-isomerase activity; IEA:EC.
 GO:0015238; F:drug transmembrane transporter activity; TAS:ProtInc.
 GO:0004769; F:steroid delta-isomerase activity; TAS:ProtInc.
 GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
 GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0001501; P:skeletal system development; TAS:ProtInc. 

Interpro

 IPR007905; EBP. 

Pfam

 PF05241; EBP 

SMART

  

PROSITE

  

PRINTS