UniProt Accession

 YBOX2_HUMAN; Q9Y2T7; D3DTP1; Q8N4P0 

Genbank Protein ID

 AF096834; CH471108; CH471108; BC033800; BC047760 

Genbank Nucleotide ID

 AAD30662.1; EAW90223.1; EAW90224.1; AAH33800.1; AAH47760.1 

Protein Name

 Y-box-binding protein 2 

Protein Synonyms/Alias

 Contrin; DNA-binding protein C; Dbpc; Germ cell-specific Y-box-binding protein; MSY2 homolog 

Gene Name

 YBX2 

Gene Synonyms/Alias

 CSDA3; MSY2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	FINRNDTKEDVFVHQ	ubiquitination	[1]
127	FVHQTAIKRNNPRKF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). 

Sequence Annotation

 DOMAIN 93 163 CSD.
 REGION 87 169 Required for cytoplasmic retention (By
 REGION 217 364 Required for mRNA-binding.  

Keyword

 Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0005844; C:polysome; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008289; F:lipid binding; IEA:Compara.
 GO:0003730; F:mRNA 3'-UTR binding; IEA:Compara.
 GO:0043021; F:ribonucleoprotein complex binding; IEA:Compara.
 GO:0045182; F:translation regulator activity; IEA:Compara.
 GO:0048255; P:mRNA stabilization; IEA:Compara.
 GO:0051100; P:negative regulation of binding; IEA:Compara.
 GO:0017148; P:negative regulation of translation; IEA:Compara.
 GO:0048599; P:oocyte development; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:0007286; P:spermatid development; IEA:Compara.
 GO:0007283; P:spermatogenesis; TAS:ProtInc.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0009386; P:translational attenuation; TAS:ProtInc. 

Interpro

 IPR019844; Cold-shock_CS.
 IPR011129; Cold_shock_prot.
 IPR002059; CSP_DNA-bd.
 IPR012340; NA-bd_OB-fold. 

Pfam

 PF00313; CSD 

SMART

 SM00357; CSP 

PROSITE

 PS00352; COLD_SHOCK 

PRINTS

 PR00050; COLDSHOCK.