UniProt Accession

 GLYC_MOUSE; P50431; Q64508; Q8R0X9 

Genbank Protein ID

 AF237702; AL596215; BC026055; X94478; X94479 

Genbank Nucleotide ID

 AAK15040.1; CAI35264.1; AAH26055.1; CAA64225.1; CAA64226.1 

Protein Name

 Serine hydroxymethyltransferase, cytosolic 

Protein Synonyms/Alias

 SHMT; Glycine hydroxymethyltransferase; Serine methylase 

Gene Name

 Shmt1 

Gene Synonyms/Alias

 Shmt 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	TLWASHEKMLSQPLK	ubiquitination	[1]
32	AEVYSIIKKESNRQR	ubiquitination	[1]
66	LGSCLNNKYSEGYPG	ubiquitination	[1]
151	THGFMTDKKKISATS	ubiquitination	[1]
369	TDGGRAEKVLEACSI	acetylation	[2]
369	TDGGRAEKVLEACSI	ubiquitination	[1]
380	ACSIACNKNTCPGDK	ubiquitination	[1]
387	KNTCPGDKSALRPSG	acetylation	[2]
451	EKLAGDEKIQSAVAT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Interconversion of serine and glycine. 

Sequence Annotation

 MOD_RES 28 28 Phosphotyrosine.
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 251 251 N6-(pyridoxal phosphate)lysine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; One-carbon metabolism; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 478 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.
 GO:0008732; F:L-allo-threonine aldolase activity; IEA:Compara.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0046655; P:folic acid metabolic process; IEA:Compara.
 GO:0019264; P:glycine biosynthetic process from serine; IEA:Compara.
 GO:0006565; P:L-serine catabolic process; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0009113; P:purine nucleobase biosynthetic process; IEA:Compara.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 

Interpro

 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase.
 IPR019798; Ser_HO-MeTrfase_PLP_BS. 

Pfam

 PF00464; SHMT 

SMART

  

PROSITE

 PS00096; SHMT 

PRINTS