CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016203
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 12 
Protein Synonyms/Alias
 ATP-binding cassette transporter 12; ATP-binding cassette 12 
Gene Name
 ABCA12 
Gene Synonyms/Alias
 ABC12 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1580HLTLTKKKSPNLNANubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Probable transporter involved in lipid homeostasis. 
Sequence Annotation
 DOMAIN 1346 1577 ABC transporter 1.
 DOMAIN 2254 2489 ABC transporter 2.
 NP_BIND 1378 1385 ATP 1 (Potential).
 NP_BIND 2290 2297 ATP 2 (Potential).
 CARBOHYD 156 156 N-linked (GlcNAc...) (Potential).
 CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
 CARBOHYD 214 214 N-linked (GlcNAc...) (Potential).
 CARBOHYD 275 275 N-linked (GlcNAc...) (Potential).
 CARBOHYD 333 333 N-linked (GlcNAc...) (Potential).
 CARBOHYD 367 367 N-linked (GlcNAc...) (Potential).
 CARBOHYD 383 383 N-linked (GlcNAc...) (Potential).
 CARBOHYD 412 412 N-linked (GlcNAc...) (Potential).
 CARBOHYD 435 435 N-linked (GlcNAc...) (Potential).
 CARBOHYD 528 528 N-linked (GlcNAc...) (Potential).
 CARBOHYD 543 543 N-linked (GlcNAc...) (Potential).
 CARBOHYD 577 577 N-linked (GlcNAc...) (Potential).
 CARBOHYD 608 608 N-linked (GlcNAc...) (Potential).
 CARBOHYD 623 623 N-linked (GlcNAc...) (Potential).
 CARBOHYD 648 648 N-linked (GlcNAc...) (Potential).
 CARBOHYD 752 752 N-linked (GlcNAc...) (Potential).
 CARBOHYD 826 826 N-linked (GlcNAc...) (Potential).
 CARBOHYD 920 920 N-linked (GlcNAc...) (Potential).
 CARBOHYD 963 963 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1170 1170 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1524 1524 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1663 1663 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1704 1704 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1769 1769 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1819 1819 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1835 1835 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1876 1876 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1921 1921 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1952 1952 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2178 2178 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2208 2208 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2223 2223 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2318 2318 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2542 2542 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2547 2547 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Disease mutation; Glycoprotein; Ichthyosis; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2595 AA 
Protein Sequence
MASLFHQLQI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT AKPTCYLAPR 60
NLPSTGFFPF LQTLLCDTDS KCKDTPYGPQ DLLRRKGIDD ALFKDSEILR KSSNLDKDSS 120
LSFQSTQVPE RRHASLATVF PSPSSDLEIP GTYTFNGSQV LARILGLEKL LKQNSTSEDI 180
RRELCDSYSG YIVDDAFSWT FLGRNVFNKF CLSNMTLLES SLQELNKQFS QLSSDPNNQK 240
IVFQEIVRML SFFSQVQEQK AVWQLLSSFP NVFQNDTSLS NLFDVLRKAN SVLLVVQKVY 300
PRFATNEGFR TLQKSVKHLL YTLDSPAQGD SDNITHVWNE DDGQTLSPSS LAAQLLILEN 360
FEDALLNISA NSPYIPYLAC VRNVTDSLAR GSPENLRLLQ STIRFKKSFL RNGSYEDYFP 420
PVPEVLKSKL SQLRNLTELL CESETFSLIE KSCQLSDMSF GSLCEESEFD LQLLEAAELG 480
TEIAASLLYH DNVISKKVRD LLTGDPSKIN LNMDQFLEQA LQMNYLENIT QLIPIIEAML 540
HVNNSADASE KPGQLLEMFK NVEELKEDLR RTTGMSNRTI DKLLAIPIPD NRAEIISQVF 600
WLHSCDTNIT TPKLEDAMKE FCNLSLSERS RQSYLIGLTL LHYLNIYNFT YKVFFPRKDQ 660
KPVEKMMELF IRLKEILNQM ASGTHPLLDK MRSLKQMHLP RSVPLTQAMY RSNRMNTPQG 720
SFSTISQALC SQGITTEYLT AMLPSSQRPK GNHTKDFLTY KLTKEQIASK YGIPINSTPF 780
CFSLYKDIIN MPAGPVIWAF LKPMLLGRIL YAPYNPVTKA IMEKSNVTLR QLAELREKSQ 840
EWMDKSPLFM NSFHLLNQAI PMLQNTLRNP FVQVFVKFSV GLDAVELLKQ IDELDILRLK 900
LENNIDIIDQ LNTLSSLTVN ISSCVLYDRI QAAKTIDEME REAKRLYKSN ELFGSVIFKL 960
PSNRSWHRGY DSGNVFLPPV IKYTIRMSLK TAQTTRSLRT KIWAPGPHNS PSHNQIYGRA 1020
FIYLQDSIER AIIELQTGRN SQEIAVQVQA IPYPCFMKDN FLTSVSYSLP IVLMVAWVVF 1080
IAAFVKKLVY EKDLRLHEYM KMMGVNSCSH FFAWLIESVG FLLVTIVILI IILKFGNILP 1140
KTNGFILFLY FSDYSFSVIA MSYLISVFFN NTNIAALIGS LIYIIAFFPF IVLVTVENEL 1200
SYVLKVFMSL LSPTAFSYAS QYIARYEEQG IGLQWENMYT SPVQDDTTSF GWLCCLILAD 1260
SFIYFLIAWY VRNVFPGTYG MAAPWYFPIL PSYWKERFGC AEVKPEKSNG LMFTNIMMQN 1320
TNPSASPEYM FSSNIEPEPK DLTVGVALHG VTKIYGSKVA VDNLNLNFYE GHITSLLGPN 1380
GAGKTTTISM LTGLFGASAG TIFVYGKDIK TDLHTVRKNM GVCMQHDVLF SYLTTKEHLL 1440
LYGSIKVPHW TKKQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV 1500
ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL EQGGLRCCGS 1560
PFYLKEAFGD GYHLTLTKKK SPNLNANAVC DTMAVTAMIQ SHLPEAYLKE DIGGELVYVL 1620
PPFSTKVSGA YLSLLRALDN GMGDLNIGCY GISDTTVEEV FLNLTKESQK NSAMSLEHLT 1680
QKKIGNSNAN GISTPDDLSV SSSNFTDRDD KILTRGERLD GFGLLLKKIM AILIKRFHHT 1740
RRNWKGLIAQ VILPIVFVTT AMGLGTLRNS SNSYPEIQIS PSLYGTSEQT AFYANYHPST 1800
EALVSAMWDF PGIDNMCLNT SDLQCLNKDS LEKWNTSGEP ITNFGVCSCS ENVQECPKFN 1860
YSPPHRRTYS SQVIYNLTGQ RVENYLISTA NEFVQKRYGG WSFGLPLTKD LRFDITGVPA 1920
NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR VNMSKYDAAR HGIIMYSHPY PGVQDQEQAT 1980
ISSLIDILVA LSILMGYSVT TASFVTYVVR EHQTKAKQLQ HISGIGVTCY WVTNFIYDMV 2040
FYLVPVAFSI GIIAIFKLPA FYSENNLGAV SLLLLLFGYA TFSWMYLLAG LFHETGMAFI 2100
TYVCVNLFFG INSIVSLSVV YFLSKEKPND PTLELISETL KRIFLIFPQF CFGYGLIELS 2160
QQQSVLDFLK AYGVEYPNET FEMNKLGAMF VALVSQGTMF FSLRLLINES LIKKLRLFFR 2220
KFNSSHVRET IDEDEDVRAE RLRVESGAAE FDLVQLYCLT KTYQLIHKKI IAVNNISIGI 2280
PAGECFGLLG VNGAGKTTIF KMLTGDIIPS SGNILIRNKT GSLGHVDSHS SLVGYCPQED 2340
ALDDLVTVEE HLYFYARVHG IPEKDIKETV HKLLRRLHLM PFKDRATSMC SYGTKRKLST 2400
ALALIGKPSI LLLDEPSSGM DPKSKRHLWK IISEEVQNKC SVILTSHSME ECEALCTRLA 2460
IMVNGKFQCI GSLQHIKSRF GRGFTVKVHL KNNKVTMETL TKFMQLHFPK TYLKDQHLSM 2520
LEYHVPVTAG GVANIFDLLE TNKTALNITN FLVSQTTLEE VFINFAKDQK SYETADTSSQ 2580
GSTISVDSQD DQMES 2595 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005524; F:ATP binding; NAS:UniProtKB.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0019725; P:cellular homeostasis; NAS:UniProtKB.
 GO:0035627; P:ceramide transport; IEA:Compara.
 GO:0061436; P:establishment of skin barrier; IEA:Compara.
 GO:0031424; P:keratinization; IEA:Compara.
 GO:0055088; P:lipid homeostasis; IEA:Compara.
 GO:0006869; P:lipid transport; NAS:UniProtKB.
 GO:0048286; P:lung alveolus development; IEA:Compara.
 GO:0043129; P:surfactant homeostasis; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS