UniProt Accession

 PR38B_HUMAN; Q5VTL8; Q05DD6; Q32Q58; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40 

Genbank Protein ID

 AK001192; AL591719; AL160171; AL591719; AL160171; AL591719; AL160171; AL160171; AL591719; AL160171; AL591719; AL160171; AL591719; BC007757; BC016296; BC024275; BC040127; BC053838; BC107801; BC130346; BC132963; AY211915 

Genbank Nucleotide ID

 BAA91546.1; CAH72068.1; CAH72068.1; CAH72069.1; CAH72069.1; CAH72070.1; CAH72070.1; CAI12932.1; CAI12932.1; CAI12933.1; CAI12933.1; CAI12934.1; CAI12934.1; AAH07757.1; AAH16296.1; AAH24275.1; AAH40127.1; AAH53838.1; AAI07802.1; AAI30347.1; AAI32964.1; AAO65168.1 

Protein Name

 Pre-mRNA-splicing factor 38B 

Protein Synonyms/Alias

 Sarcoma antigen NY-SAR-27 

Gene Name

 PRPF38B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	THVEPWEKGSRKTAG	ubiquitination	[1]
105	PWEKGSRKTAGQTGM	ubiquitination	[2]
227	RIPVPVQKNIDQQIK	acetylation	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 May be required for pre-mRNA splicing (Potential). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 35 35 Phosphothreonine (By similarity).
 MOD_RES 227 227 N6-acetyllysine.
 MOD_RES 320 320 Phosphoserine.
 MOD_RES 448 448 Phosphoserine.
 MOD_RES 473 473 Phosphoserine.
 MOD_RES 475 475 Phosphoserine.
 MOD_RES 481 481 Phosphoserine.
 MOD_RES 527 527 Phosphoserine.
 MOD_RES 529 529 Phosphoserine.
 MOD_RES 534 534 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 546 AA 

Protein Sequence

Gene Ontology

 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR005037; PRP38. 

Pfam

 PF03371; PRP38 

SMART

  

PROSITE

  

PRINTS