CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038548
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Voltage-dependent L-type calcium channel subunit alpha-1S 
Protein Synonyms/Alias
  
Gene Name
 Cacna1s 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
719EGIPTTAKLKIDEFEubiquitination[1]
769AELQLKEKAVPIPEAubiquitination[1]
1414AEYDPEAKGRIKHLDubiquitination[1]
1550YYGYRPKKDTVQIQAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Calcium channel; Calcium transport; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1850 AA 
Protein Sequence
MEPPSPQDEG LRKKQPKKPV PEILPRPPRA LFCLTLQNPL RKACISIVEW KPFETIILLT 60
IFANCVALAV YLPMPEDDNN TLNLGLEKLE YFFLIVFSIE AAMKIIAYGF LFHQDAYLRS 120
GWNVLDFIIV FLGVFTVILE QVNIIQTNTA PMSSKGAGLD VKALRAFRVL RPLRLVSGVP 180
SLQVVLNSIF KAMLPLFHIA LLVLFMVIIY AIIGLELFKG KMHKTCYFIG TDIVATVENE 240
KPSPCARTGS GRPCTINGSE CRGGWPGPNH GITHFDNFGF SMLTVYQCIS MEGWTDVLYW 300
VNDAIGNEWP WIYFVTLILL GSFFILNLVL GVLSGEFTKE REKAKSRGTF QKLREKQQLE 360
EDLRGYMSWI TQGEVMDVDD LREGKLSLDE GGSDTESLYE IEGLNKIIQF IRHWRQWNRV 420
FRWKCHDLVK SKVFYWLVIL IVALNTLSIA SEHHNQPLWL THLQDVANRV LLTLFTIEML 480
MKMYGLGLRQ YFMSIFNRFD CFVVCSGILE ILLVESGAMS PLGISVLRCI RLLRLFKITK 540
YWTSLSNLVA SLLNSIRSIA SLLLLLFLFI IIFALLGMQL FGGRYDFEDT EVRRSNFDNF 600
PQALISVFQV LTGEDWNSVM YNGIMAYGGP TYPGVLVCIY FIILFVCGNY ILLNVFLAIA 660
VDNLAEAESL TSAQKAKAEE RKRRKMSKGL PDKSEEERAT VTKKLEQKSK GEGIPTTAKL 720
KIDEFESNVN EVKDPYPSAD FPGDDEEDEP EIPVSPRPRP LAELQLKEKA VPIPEASSFF 780
IFSPTNKIRV LCHRIVNATW FTNFILLFIL LSSAALAAED PIRADSMRNQ ILEYFDYVFT 840
AVFTVEIVLK MTTYGAFLHK GSFCRNYFNI LDLLVVAVSL ISMGLESSAI SVVKILRVLR 900
VLRPLRAINR AKGLKHVVQC VFVAIRTIGN IVLVTTLLQF MFACIGVQLF KGKFYSCNDL 960
SKMTEEECRG YYYIYKDGDP TQIELRPRQW IHNDFHFDNV LSAMMSLFTV STFEGWPQLL 1020
YKAIDSNEED TGPVYNNRVE MAIFFIIYII LIAFFMMNIF VGFVIVTFQE QGETEYKNCE 1080
LDKNQRQCVQ YALKARPLRC YIPKNPYQYQ VWYVVTSSYF EYLMFALIML NTICLGMQHY 1140
NQSEQMNHIS DILNVAFTII FTLEMVLKLI AFKPRGYFGD PWNVFDFLIV IGSIIDVILS 1200
EIDTFLASSG GLYCLGGGCG NVDPDESARI SSAFFRLFRV MRLVKLLNRA EGVRTLLWTF 1260
IKSFQALPYV ALLIVMLFFI YAVIGMQMFG KIAMVDGTQI NRNNNFQTFP QAVLLLFRCA 1320
TGEAWQEILL ACSYGKLCDP ESDYAPGEEH TCGTNFAYYY FISFYMLCAF LIINLFVAVI 1380
MDNFDYLTRD WSILGPHHLD EFKAIWAEYD PEAKGRIKHL DVVTLLRRIQ PPLGFGKFCP 1440
HRVACKRLVG MNMPLNSDGT VTFNATLFAL VRTALKIKTE GNFEQANEEL RAIIKKIWKR 1500
TSMKLLDQVI PPIGDDEVTV GKFYATFLIQ EHFRKFMKRQ EEYYGYRPKK DTVQIQAGLR 1560
TIEEEAAPEI HRAISGDLTA EEELERAMVE AAMEEGIFRR TGGLFGQVDN FLERTNSLPP 1620
VMANQRPLQF AEIEMEELES PVFLEDFPQN PGTHPLARAN TNNANANVAY GNSSHRNNPV 1680
FSSICYEREF LGEADMPVTR EGPLSQPCRA SGPHSRSHVD KLKRPMTQRG MPEGQVPPSP 1740
CQLSQAEHPV QKEGKGPTSR FLETPNSRNF EEHVPRNSAH RCTAPATAML IQEALVRGGL 1800
DSLAADANFV MATGQALADA CQMEPEEVEV AATELLKQES PEGGAVPWEP 1850 
Gene Ontology
 GO:0016529; C:sarcoplasmic reticulum; IDA:MGI.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
 GO:0005245; F:voltage-gated calcium channel activity; IDA:MGI.
 GO:0007029; P:endoplasmic reticulum organization; IMP:MGI.
 GO:0002074; P:extraocular skeletal muscle development; IMP:MGI.
 GO:0007520; P:myoblast fusion; IMP:MGI.
 GO:0007528; P:neuromuscular junction development; IMP:MGI.
 GO:0043501; P:skeletal muscle adaptation; IMP:MGI.
 GO:0001501; P:skeletal system development; IMP:MGI.
 GO:0006941; P:striated muscle contraction; IMP:MGI. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR014873; VDCC_a1su_IQ.
 IPR005450; VDCC_L_a1ssu.
 IPR005446; VDCC_L_a1su.
 IPR002077; VDCCAlpha1. 
Pfam
 PF08763; Ca_chan_IQ
 PF00520; Ion_trans 
SMART
 SM01062; Ca_chan_IQ 
PROSITE
  
PRINTS
 PR00167; CACHANNEL.
 PR01630; LVDCCALPHA1.
 PR01634; LVDCCALPHA1S.