UniProt Accession

 FIP1_RAT; Q5U317 

Genbank Protein ID

 BC085767 

Genbank Nucleotide ID

 AAH85767.1 

Protein Name

 Pre-mRNA 3'-end-processing factor FIP1 

Protein Synonyms/Alias

 FIP1-like 1 protein 

Gene Name

 Fip1l1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
514	HKKSKRSKEGKEAGS	acetylation	[1]
517	SKRSKEGKEAGSEPV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). 

Sequence Annotation

 REGION 1 296 Necessary for stimulating PAPOLA activity
 REGION 1 110 Sufficient for interaction with PAPOLA
 REGION 136 219 Sufficient for interaction with CPSF4 (By
 REGION 383 536 Sufficient for interaction with CPSF1 and
 MOD_RES 84 84 Phosphoserine (By similarity).
 MOD_RES 86 86 Phosphoserine (By similarity).
 MOD_RES 88 88 Phosphoserine (By similarity).
 MOD_RES 235 235 Phosphoserine (By similarity).
 MOD_RES 366 366 Phosphotyrosine (By similarity).
 MOD_RES 434 434 Phosphoserine (By similarity).
 MOD_RES 436 436 Phosphothreonine (By similarity).
 MOD_RES 438 438 Phosphoserine (By similarity).
 MOD_RES 442 442 Phosphoserine (By similarity).
 MOD_RES 496 496 Phosphoserine (By similarity).  

Keyword

 Complete proteome; mRNA processing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 536 AA 

Protein Sequence

Gene Ontology

 GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR007854; Fip1. 

Pfam

 PF05182; Fip1 

SMART

  

PROSITE

  

PRINTS