CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009833
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60S ribosomal protein L22 
Protein Synonyms/Alias
 Heparin-binding protein HBp15 
Gene Name
 Rpl22 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
52ERIKVNGKAGNLGGGubiquitination[1]
69TIERSKSKITVTSEVacetylation[2]
69TIERSKSKITVTSEVsuccinylation[2]
80TSEVPFSKRYLKYLTacetylation[2, 3, 4]
80TSEVPFSKRYLKYLTsuccinylation[2]
84PFSKRYLKYLTKKYLacetylation[4]
107LRVVANSKESYELRYacetylation[4]
107LRVVANSKESYELRYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Heparin-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 128 AA 
Protein Sequence
MAPVKKLVAK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN GKAGNLGGGV 60
VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL RVVANSKESY ELRYFQINQD 120
EEEEEDED 128 
Gene Ontology
 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0005840; C:ribosome; IDA:MGI.
 GO:0008201; F:heparin binding; IDA:MGI.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0046632; P:alpha-beta T cell differentiation; IMP:MGI.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR002671; Ribosomal_L22e. 
Pfam
 PF01776; Ribosomal_L22e 
SMART
  
PROSITE
  
PRINTS