UniProt Accession

 B2CL1_RAT; P53563; P70613; P70614; Q52KS0; Q62678; Q62836; Q64087; Q64128 

Genbank Protein ID

 X82537; X82537; U10579; U72350; U72349; U34963; S76513; S78284; BC094213 

Genbank Nucleotide ID

 CAA57886.1; CAA57887.1; AAA19257.1; AAB17353.1; AAB17352.1; AAA77686.1; AAC60701.2; AAC60702.1; AAH94213.1 

Protein Name

 Bcl-2-like protein 1 

Protein Synonyms/Alias

 Bcl2-L-1; Apoptosis regulator Bcl-X 

Gene Name

 Bcl2l1 

Gene Synonyms/Alias

 Bclx; Blc2l 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
87	VIPMAAVKQALREAG	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. 

Sequence Annotation

 MOTIF 4 24 BH4.
 MOTIF 86 100 BH3.
 MOTIF 129 148 BH1.
 MOTIF 180 195 BH2.
 MOD_RES 49 49 Phosphoserine; by PLK3 (By similarity).
 MOD_RES 62 62 Phosphoserine; by CDK1 (By similarity).  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 233 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:RGD.
 GO:0000910; P:cytokinesis; ISS:UniProtKB.
 GO:0007093; P:mitotic cell cycle checkpoint; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
 GO:0001541; P:ovarian follicle development; IMP:RGD.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0010288; P:response to lead ion; IEP:RGD.
 GO:0014070; P:response to organic cyclic compound; IEP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IEP:RGD. 

Interpro

 IPR013279; Apop_reg_BclX.
 IPR002475; Bcl2-like.
 IPR004725; Bcl2/BclX.
 IPR020717; Bcl2_BH1_motif_CS.
 IPR020726; Bcl2_BH2_motif_CS.
 IPR020728; Bcl2_BH3_motif_CS.
 IPR003093; Bcl2_BH4.
 IPR020731; Bcl2_BH4_motif_CS.
 IPR026298; Blc2_fam. 

Pfam

 PF00452; Bcl-2
 PF02180; BH4 

SMART

 SM00265; BH4 

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2
 PS01259; BH3
 PS01260; BH4_1
 PS50063; BH4_2 

PRINTS

 PR01864; APOPREGBCLX.
 PR01862; BCL2FAMILY.