CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 
Protein Synonyms/Alias
 Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha 
Gene Name
 l(1)G0156 
Gene Synonyms/Alias
 CG12233 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
93PVRGPDGKFGIPQAAacetylation[1]
216KKVTVVHKANIMRMSacetylation[1]
341ELNTYADKIERAAFEacetylation[1]
354FETIKEGKYLTGDLGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
 METAL 249 249 Magnesium or manganese (By similarity).
 METAL 273 273 Magnesium or manganese (By similarity).
 METAL 277 277 Magnesium or manganese (By similarity).
 BINDING 131 131 Substrate (By similarity).
 BINDING 141 141 Substrate (By similarity).
 BINDING 162 162 Substrate (By similarity).
 BINDING 249 249 Substrate (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MAARFIQKIL NQLGLIAARD APAVTATPAV SQVNATPAAS RSYSSGTKKV TLIPGDGIGP 60
EISAAVQKIF TAANVPIEWE AVDVTPVRGP DGKFGIPQAA IDSVNTNKIG LKGPLMTPVG 120
KGHRSLNLAL RKEFNLYANV RPCRSLEGYK TLYDDVDVVT IRENTEGEYS GIEHEIVDGV 180
VQSIKLITEE ASKRVAEYAF QYAKNNNRKK VTVVHKANIM RMSDGLFLRC VRDMAQKFPE 240
IQFEEKYLDT VCLNMVQNPG KYDVLVMPNL YGDILSDMCA GLVGGLGLTP SGNMGLNGAL 300
FESVHGTAPD IAGKDLANPT ALLLSAVMML RHMELNTYAD KIERAAFETI KEGKYLTGDL 360
GGRAKCSEFT NEICAKL 377 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; ISS:UniProtKB. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR004434; Isocitrate_DH_NAD.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS