| Tag | Content |
|---|
| CPLM ID | CPLM-008814 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Monocarboxylate transporter 1 |
Protein Synonyms/Alias | MCT 1; Solute carrier family 16 member 1 |
Gene Name | Slc16a1 |
Gene Synonyms/Alias | Mct1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 211 | KLEKLKSKESLQEAG | ubiquitination | [1] | | 219 | ESLQEAGKSDANTDL | ubiquitination | [1] | | 232 | DLIGGSPKGEKLSVF | ubiquitination | [1] | | 456 | EKQKREGKEDEASTD | ubiquitination | [1] | | 467 | ASTDVDEKPKETMKA | ubiquitination | [1] | | 469 | TDVDEKPKETMKAAQ | ubiquitination | [1] | | 473 | EKPKETMKAAQSPQQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. |
Sequence Annotation | MOD_RES 210 210 Phosphoserine.
MOD_RES 213 213 Phosphoserine.
MOD_RES 230 230 Phosphoserine.
MOD_RES 461 461 Phosphoserine.
MOD_RES 462 462 Phosphothreonine.
MOD_RES 477 477 Phosphoserine.
MOD_RES 491 491 Phosphoserine. |
Keyword | Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 493 AA |
Protein Sequence | MPPAIGGPVG YTPPDGGWGW AVLVGAFISI GFSYAFPKSI TVFFKEIEVI FSATTSEVSW 60
ISSIMLAVMY AGGPISSILV NKYGSRPVMI AGGCLSGCGL IAASFCNTVQ ELYLCIGVIG 120
GLGLAFNLNP ALTMIGKYFY KKRPLANGLA MAGSPVFLST LAPLNQAFFD IFDWRGSFLI 180
LGGLLLNCCV AGSLMRPIGP EQVKLEKLKS KESLQEAGKS DANTDLIGGS PKGEKLSVFQ 240
TINKFLDLSL FTHRGFLLYL SGNVVMFFGL FTPLVFLSSY GKSKDFSSEK SAFLLSILAF 300
VDMVARPSMG LAANTKWIRP RIQYFFAASV VANGVCHLLA PLSTTYVGFC VYAGVFGFAF 360
GWLSSVLFET LMDLIGPQRF SSAVGLVTIV ECCPVLLGPP LLGRLNDMYG DYKYTYWACG 420
VILIIAGIYL FIGMGINYRL LAKEQKAEEK QKREGKEDEA STDVDEKPKE TMKAAQSPQQ 480
HSSGDPTEEE SPV 493 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005739; C:mitochondrion; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0015355; F:secondary active monocarboxylate transmembrane transporter activity; IEA:InterPro. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |