UniProt Accession

 RGS8_MOUSE; Q8BXT1; Q505F2 

Genbank Protein ID

 AK044337; AK142301; BC065056; BC094577 

Genbank Nucleotide ID

 BAC31874.1; BAE25020.1; AAH65056.1; AAH94577.1 

Protein Name

 Regulator of G-protein signaling 8 

Protein Synonyms/Alias

 RGS8 

Gene Name

 Rgs8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
133	QTREATRKNMQEPSL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity). 

Sequence Annotation

 DOMAIN 56 171 RGS.  

Keyword

 Complete proteome; Reference proteome; Signal transduction inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 180 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:MGI.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam. 

Pfam

 PF00615; RGS 

SMART

 SM00315; RGS 

PROSITE

 PS50132; RGS 

PRINTS

 PR01301; RGSPROTEIN.