CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044421
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Apolipoprotein L2 
Protein Synonyms/Alias
  
Gene Name
 APOL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
305QSGTNVAKVMKEFVGubiquitination[1, 2, 3, 4, 5]
415KHLLEGAKSESAEELacetylation[6, 7]
415KHLLEGAKSESAEELubiquitination[4, 5]
432RAQELEGKLNFLTKIubiquitination[1, 4, 5]
438GKLNFLTKIHEMLQPubiquitination[1, 2, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 449 AA 
Protein Sequence
MHSWTWDPHS SEQLDLAQSL SEEDPLSSLR GSIQPQPPAE APDKGGSQAN NDPGGWDPGC 60
SSSQVLGRTR GPCLGVRVRE EEAGTRVKEN LPVWTVTGEL QGKPLGNPAA GTMNPESSIF 120
IEDYLKYFQD QVSRENLLQL LTDDEAWNGF VAAAELPRDE ADELRKALNK LASHMVMKDK 180
NRHDKDQQHR QWFLKEFPRL KRELEDHIRK LRALAEEVEQ VHRGTTIANV VSNSVGTTSG 240
ILTLLGLGLA PFTEGISFVL LDTGMGLGAA AAVAGITCSV VELVNKLRAR AQARNLDQSG 300
TNVAKVMKEF VGGNTPNVLT LVDNWYQVTQ GIGRNIRAIR RARANPQLGA YAPPPHIIGR 360
ISAEGGEQVE RVVEGPAQAM SRGTMIVGAA TGGILLLLDV VSLAYESKHL LEGAKSESAE 420
ELKKRAQELE GKLNFLTKIH EMLQPGQDQ 449 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:InterPro.
 GO:0008289; F:lipid binding; IEA:InterPro.
 GO:0006869; P:lipid transport; IEA:InterPro.
 GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. 
Interpro
 IPR008405; ApoL. 
Pfam
 PF05461; ApoL 
SMART
  
PROSITE
  
PRINTS