CPLM-013958

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-013958

UniProt Accession

UBX11_HUMAN; Q5T124; D3DPK6; Q5T117; Q5T120; Q5T125; Q5T126; Q5T129; Q5T131; Q5T133; Q63HM6; Q71RB3; Q8IY27; Q8N1L6; Q8N9M4; Q8NA18; Q8NFE3; Q8NFE4; Q8NFE6

Genbank Protein ID

AF521017; AF521018; AF520989; CR749413; BX648412; AK093258; AK094198; AK097368; AF370425; AL451139; AL451139; AL451139; AL451139; AL451139; AL451139; AL451139; AL451139; CH471059; CH471059; BC038106

Genbank Nucleotide ID

AAM74201.1; AAM74202.1; AAM76060.1; CAH18255.1; CAH56155.1; BAC04112.1; BAC04307.1; BAC05024.1; AAQ15261.1; CAI15828.1; CAI15832.1; CAI15833.1; CAI15834.1; CAI15835.1; CAI15836.1; CAI15840.1; CAI15842.1; EAX07823.1; EAX07826.1; AAH38106.1

Protein Name

UBX domain-containing protein 11

Protein Synonyms/Alias

Colorectal tumor-associated antigen COA-1; Socius; UBX domain-containing protein 5

Gene Name

UBXN11

Gene Synonyms/Alias

SOC; UBXD5; PP2243

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
100	QTDEILSKDQKIAAL	ubiquitination	[1]
182	RDWMTAKKFWKPGDS	ubiquitination	[1]
236	TLEPIPLKLYRNGIM	ubiquitination	[1]
284	YPNGVPFKVSDLRNQ	ubiquitination	[1]
402	PLSMLRIKSENGEQA	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).

Sequence Annotation

DOMAIN 230 294 SEP.
DOMAIN 392 469 UBX.
REPEAT 487 494 1.
REPEAT 495 502 2.
REPEAT 503 510 3.
REGION 487 510 3 X 8 AA tandem repeats of P-G-P-G-P-G-P-

Keyword

Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome; Repeat.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

520 AA

Protein Sequence

MSSPLASLSK TRKVPLPSEP MNPGRRGIRI YGDEDEVDML SDGCGSEEKI SVPSCYGGIG 60
APVSRQVPAS HDSELMAFMT RKLWDLEQQV KAQTDEILSK DQKIAALEDL VQTLRPHPAE 120
ATLQRQEELE TMCVQLQRQV REMERFLSDY GLQWVGEPMD QEDSESKTVS EHGERDWMTA 180
KKFWKPGDSL APPEVDFDRL LASLQDLSEL VVEGDTQVTP VPGGARLRTL EPIPLKLYRN 240
GIMMFDGPFQ PFYDPSTQRC LRDILDGFFP SELQRLYPNG VPFKVSDLRN QVYLEDGLDP 300
FPGEGRVVGR QLMHKALDRV EEHPGSRMTA EKFLNRLPKF VIRQGEVIDI RGPIRDTLQN 360
CCPLPARIQE IVVETPTLAA ERERSQESPN TPAPPLSMLR IKSENGEQAF LLMMQPDNTI 420
GDVRALLAQA RVMDASAFEI FSTFPPTLYQ DDTLTLQAAG LVPKAALLLR ARRAPKSSLK 480
FSPGPCPGPG PGPSPGPGPG PSPGPGPGPS PCPGPSPSPQ 520

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.

Interpro

IPR012989; SEP_domain.
IPR001012; UBX.

Pfam

PF08059; SEP

SMART

SM00166; UBX

PROSITE

PS51399; SEP
PS50033; UBX

PRINTS