CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039877
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Porphobilinogen deaminase 
Protein Synonyms/Alias
  
Gene Name
 HMBS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
196LGVEVRAKDQDILDLubiquitination[1]
317LLLSKGAKNILDVARubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 330 AA 
Protein Sequence
MSGNGNAAAT ALARIQTDSV VATLKASYPG LQFEIIAMST TGDKILDTAL SKIGEKSLFT 60
KELEHALEKN EVDLVVHSLK DLPTVLPPGF TIGAICKREN PHDAVVFHPK FVGKTLETLP 120
EKSVVGTSSL RRAAQLQRKF PHLEFRSIRG NLNTRLRKLD EQQEFSAIIL ATAGLQRMGW 180
HNRVGQGALG VEVRAKDQDI LDLVGVLHDP ETLLRCIAER AFLRHLEGGC SVPVAVHTAM 240
KDGQLYLTGG VWSLDGSDSI QETMQATIHV PAQHEDGPED DPQLVGITAR NIPRGPQLAA 300
QNLGISLANL LLSKGAKNIL DVARQLNDAH 330 
Gene Ontology
 GO:0004418; F:hydroxymethylbilane synthase activity; IEA:InterPro.
 GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
 GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro. 
Interpro
 IPR000860; 4pyrrol_synth_OHMeBilane_synth.
 IPR022419; Porphobilin_deaminase_cofac_BS.
 IPR022417; Porphobilin_deaminase_N.
 IPR022418; Porphobilinogen_deaminase_C. 
Pfam
 PF01379; Porphobil_deam
 PF03900; Porphobil_deamC 
SMART
  
PROSITE
 PS00533; PORPHOBILINOGEN_DEAM 
PRINTS
 PR00151; PORPHBDMNASE.