CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016083
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin-associated protein 2-like 
Protein Synonyms/Alias
  
Gene Name
 Ubap2l 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
249EGSNYPRKFETAPGAacetylation[1]
249EGSNYPRKFETAPGAsuccinylation[1]
249EGSNYPRKFETAPGAubiquitination[2]
364SMVSMLGKGFGDVGEubiquitination[2]
373FGDVGEAKGGSTTGSubiquitination[2]
884PYSGDLTKFGRGDASubiquitination[2]
1091QTSSIPQKPQTNKSAacetylation[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 DOMAIN 49 89 UBA.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 436 436 Phosphoserine (By similarity).
 MOD_RES 445 445 Phosphothreonine (By similarity).
 MOD_RES 474 474 Phosphoserine (By similarity).
 MOD_RES 487 487 Phosphoserine (By similarity).
 MOD_RES 490 490 Phosphoserine (By similarity).
 MOD_RES 491 491 Phosphoserine (By similarity).
 MOD_RES 497 497 Phosphoserine.
 MOD_RES 513 513 Phosphoserine (By similarity).
 MOD_RES 625 625 Phosphoserine.
 MOD_RES 628 628 Phosphoserine (By similarity).
 MOD_RES 629 629 Phosphoserine.
 MOD_RES 872 872 Phosphoserine (By similarity).
 MOD_RES 879 879 Phosphoserine (By similarity).  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1107 AA 
Protein Sequence
MMTSVGTNRA RGNWEQPQNQ NQTQHKQRPQ ATAEQIRLAQ MISDHNDADF EEKVKQLIDI 60
TGKNQDECVI ALHDCNGDVN RAINVLLEGN PDTHSWEMVG KKKGVSGQKD GGQTESNEEG 120
KENRDRDRDY SRRRGGPPRR GRGASRGREF RGQENGLDGT KSGGPSGRGT DRGRRGRGRG 180
RGSSGRRGGR FSAQGMGTFN PADYAEPANT DDNYGNSSGN TWNNTGHFEP DDGTRLDFIG 240
VEGSNYPRKF ETAPGAWRTA TEEWGTEDWN EDLSETKIFT ASNVSSVPLP AENVTITAGQ 300
RIDLAVLLGK TPSSMENDSS NLDPSQAPSL AQPLVFSNSK QNAISQPASG STFSHHSMVS 360
MLGKGFGDVG EAKGGSTTGS QFLEQFKTAQ ALAQLAAQHS QSGSTTTSSW DMGSTTQSPS 420
LVQYDLKSAN DSTVHSPFTK RQAFTPSSTM MEVFLQEKPP AVATSTAAPP PPSSPLPSKS 480
TSAPQMSPGS SDNQSSSPQP AQQKLKQQKK KTSLTSKIPA LAVEMPGSAD ISGLNLQFGA 540
LQFGSEPVLS DYESTPTTSA SSSQAPSSLY TSTASESSST VSSNQSQESG YQSGPIQSTT 600
YTSQNNAQGP LYEQRSTQTR RYPSSISSSP QKDLTQAKNG FSSVQATQLQ TTQSVEGATG 660
SAVKSESPST SSIPSLNETV PAASLLTTAN QHSSSLSGLS HTEEIPNTTT TQHSSALSTQ 720
QNTLSSSTSS GRTSTSTLLH TSVESEANLH SSSSTFSTTS STVSAPPPVV SVSSSLNSGS 780
SLGLSLGSNS TVTASTRSSV ATTSGKAPPN LPPGVPPLLP NPYIMAPGLL HAYPPQVYGY 840
DDLQMLQTRF PLDYYSIPFP TPTTPLTGRD GSLASNPYSG DLTKFGRGDA SSPAPATTLA 900
QPQQNQTQTH HTTQQTFLNP ALPPGYSYTS LPYYTGVPGL PSTFQYGPAV FPVAPTSSKQ 960
HGVNVSVNAS ATPFQQPSGY GSHGYNTGVS VTSSNTGVPD ISGSVYSKTQ QSFEKQGFHS 1020
GTPAASFNLP SALGSGGPIN PATAAAYPPA PFMHILTPHQ QPHSQILHHH LQQDGQTGSG 1080
QRSQTSSIPQ KPQTNKSAYN SYSWGAN 1107 
Gene Ontology
 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IEA:Compara.
 GO:0007339; P:binding of sperm to zona pellucida; IEA:Compara. 
Interpro
 IPR022166; DUF3697_Uba2.
 IPR009060; UBA-like.
 IPR015940; UBA/transl_elong_EF1B_N_euk. 
Pfam
 PF12478; DUF3697 
SMART
 SM00165; UBA 
PROSITE
 PS50030; UBA 
PRINTS