| Tag | Content |
|---|
| CPLM ID | CPLM-024436 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Autophagy-related protein 13 |
Protein Synonyms/Alias | |
Gene Name | ATG13 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Pan troglodytes (Chimpanzee) |
NCBI Taxa ID | 9598 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 143 | PAYRLSRKQGHEYVI | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). |
Sequence Annotation | MOTIF 407 410 LIR (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 318 318 Phosphoserine; by ULK1 (By similarity).
MOD_RES 324 324 Phosphoserine (By similarity). |
Keyword | Acetylation; Autophagy; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 474 AA |
Protein Sequence | METDLNSQDR KDLDKFIKFF ALKTVQVIVQ ARLGEKICTR SSSSPTGSDW FNLAIKDIPE 60
ITHEAKKALA GQLPAVGRSM CVEISLKTSE GDSMELEIWC LEMNEKCDKE IKVSYTVYNR 120
LSLLLKSLLA ITRVTPAYRL SRKQGHEYVI LYRIYFGEVQ LSGLGEGFQT VRVGTVGTPV 180
GTITLSCAYR INLAFMSTRQ FERTPPIMGI IIDHFVDRPY PSSSPMHPCN YRTAGEDTGV 240
IYPSVEDSQE VCTTSFSTSP PSQLMVPGKE GGVPLAPNQP VHGTHADQER LATCTPSDGT 300
HCAATPSSSE DTETVSNSSE GRASPHDVLE TIFVRKVGAF VNKPINQVTL TSLDIPFAMF 360
APKNLELEDT DPMVNPPDSP ETESPLQGSL HSDGSSGGSS GNTHDDFVMI DFKPAFSKDD 420
ILPMDLGTFY REFQNPPQLS SLSIDIGAQS MAEDLDSLPE KNVREFDAFV ETLQ 474 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0000407; C:pre-autophagosomal structure; ISS:UniProtKB. GO:0000045; P:autophagic vacuole assembly; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |