Tag | Content |
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CPLM ID | CPLM-016744 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein phosphatase 1 regulatory subunit 3B |
Protein Synonyms/Alias | Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; PP1 subunit R4; Protein phosphatase 1 subunit GL; PTG |
Gene Name | Ppp1r3b |
Gene Synonyms/Alias | Ppp1r4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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242 | ELRSSPGKIEPYNGP | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). |
Sequence Annotation | DOMAIN 124 232 CBM21. MOTIF 61 64 PP1-binding motif. |
Keyword | Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 284 AA |
Protein Sequence | MAVDIQYSYS SMAPSLRRER FTFKISPKLS KPLRPCIQLG SKDEASGMVA PAVQEKKVKK 60 RVSFADNQGL ALTMVKVFSE FDDPLDIPFN ITELLDNIVS LTTAESESFV LDFPQPSADY 120 LDFRNRLQTN HVCLENCVLK DKAIAGTVKV QNLAFEKVVK IRMTFDTWKS FTDFPCQYVK 180 DTYAGSDRDT FSFDISLPEK IQSYERMEFA VCYECNGQAY WDSNKGKNYR ITRAELRSSP 240 GKIEPYNGPD FGISFDQFGS PRCSFGLFPE WPSYLGYEKL GPYY 284 |
Gene Ontology | GO:0042587; C:glycogen granule; IEA:Compara. GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara. GO:0000164; C:protein phosphatase type 1 complex; IEA:Compara. GO:0019888; F:protein phosphatase regulator activity; IEA:Compara. GO:0005977; P:glycogen metabolic process; TAS:MGI. GO:0005979; P:regulation of glycogen biosynthetic process; IEA:Compara. GO:0005981; P:regulation of glycogen catabolic process; IEA:Compara. |
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