CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027393
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoenolpyruvate carboxykinase 
Protein Synonyms/Alias
  
Gene Name
 PEPCK 
Gene Synonyms/Alias
 PF13_0234 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
32VRRNLIYKKPIGPIMacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Lyase; Pyruvate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 583 AA 
Protein Sequence
MVEKSSDYDL AEKMEDMKKI VIEEVRRNLI YKKPIGPIMS SKDILTLSQE QESKFNEEVH 60
ELGLHVNSIH HNSTPAFLYE MALKYEGNSF ITSTGALCCI SGEKTGRSPS DKRIVQEKSS 120
EDDIWWGNVN IPIKEKSYEI NKSRAIDYLN LQPNLYVIDA YAGWDERCRI KVRVITSRAY 180
HALYMLNMLI PPKNAEEIQN FVPDFIIYNA GEFPSNRLTD GMSSKTSVIL NFGSMNMVIL 240
GTQYAGEMKK GILTLFMYKM PKEGKLPLHS SCNIGKKNDV TLFFGLSGTG KTTLSADANR 300
YLIGDDEHVW TDDGIFNIEG GCYAKCKGLS KRQEPEIYKA IKFGAILENV VMDPVTREVD 360
YNNCTITENT RCAYPLSYIE NAKIPAYIHT HPQNIILLTC DAFGVIPPLC KLDVYQMMYH 420
FVSGYTSKMA GTEDNILKPT ATFSSCYAAP FLALHPMIYA QMLADKYQKH KPNVWLLNTG 480
WIYGSYGSDN GIRIPLKYTR LLVDYIHENK LNNIQYKKTP IFNFNIPEHL EGIPDEVIDP 540
LIGWKDKEDY LTNLQILAKE FINNFSLYLD KAGPEILSGG PNL 583 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0004612; F:phosphoenolpyruvate carboxykinase (ATP) activity; IEA:EC.
 GO:0006094; P:gluconeogenesis; IEA:InterPro. 
Interpro
 IPR001272; PEP_carboxykinase_ATP.
 IPR013035; PEP_carboxykinase_C.
 IPR008210; PEP_carboxykinase_N.
 IPR015994; PEPCK_ATP_CS. 
Pfam
 PF01293; PEPCK_ATP 
SMART
  
PROSITE
 PS00532; PEPCK_ATP 
PRINTS