| Tag | Content |
|---|
| CPLM ID | CPLM-002483 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acyl-CoA desaturase 1 |
Protein Synonyms/Alias | Delta(9)-desaturase 1; Delta-9 desaturase 1; Fatty acid desaturase 1; Stearoyl-CoA desaturase 1 |
Gene Name | Scd1 |
Gene Synonyms/Alias | Scd |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 198 | AVKEKGGKLDMSDLK | ubiquitination | [1] | | 208 | MSDLKAEKLVMFQRR | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. |
Sequence Annotation | MOTIF 119 124 Histidine box-1.
MOTIF 156 160 Histidine box-2.
MOTIF 297 301 Histidine box-3. |
Keyword | Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Iron; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 358 AA |
Protein Sequence | MPAHMLQEIS SSYTTTTTIT EPPSGNLQNG REKMKKVPLY LEEDIRPEMR EDIHDPSYQD 60
EEGPPPKLEY VWRNIILMAL LHVGALYGIT LIPSSKVYTL LWGIFYYLIS ALGITAGAHR 120
LWSHRTYKAR LPLRIFLIIA NTMAFQNDVY EWARDHRAHH KFSETHADPH NSRRGFFFSH 180
VGWLLVRKHP AVKEKGGKLD MSDLKAEKLV MFQRRYYKPG LLLMCFILPT LVPWYCWGET 240
FLHSLFVSTF LRYTLVLNAT WLVNSAAHLY GYRPYDKNIQ SRENILVSLG AVGEGFHNYH 300
HAFPYDYSAS EYRWHINFTT FFIDCMAALG LAYDRKKVSK AAVLARIKRT GDGSHKSS 358 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; TAS:RGD. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0004768; F:stearoyl-CoA 9-desaturase activity; IDA:RGD. GO:0050873; P:brown fat cell differentiation; IEA:Compara. GO:0034435; P:cholesterol esterification; IEA:Compara. GO:0050830; P:defense response to Gram-positive bacterium; IEA:Compara. GO:0006633; P:fatty acid biosynthetic process; TAS:RGD. GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Compara. GO:0050872; P:white fat cell differentiation; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |