| Tag | Content |
|---|
| CPLM ID | CPLM-014386 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily A member 6 |
Protein Synonyms/Alias | MK1.6; Voltage-gated potassium channel subunit Kv1.6 |
Gene Name | Kcna6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 5 | ***MRSEKSLTLAAP | ubiquitination | [1] | | 490 | GQPTPDLKATDNGLG | ubiquitination | [1] | | 498 | ATDNGLGKPDFAEAS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
Sequence Annotation | MOTIF 422 427 Selectivity filter (By similarity).
MOTIF 527 529 PDZ-binding (Potential).
MOD_RES 8 8 Phosphothreonine.
MOD_RES 511 511 Phosphoserine; by PKA (Probable).
LIPID 285 285 S-palmitoyl cysteine (Potential).
CARBOHYD 46 46 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Ion channel; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 529 AA |
Protein Sequence | MRSEKSLTLA APGEVRGPEG EQQDAGEFQE AEGGGGCCSS ERLVINISGL RFETQLRTLS 60
LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFMEE 120
IRFYQLGEEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 180
VLVILISIVI FCLETLPQFR ADGRGGSNEG SGTRLSPASR SHEEEDEDED SYAFPGSIPS 240
GGLGTGGTSS LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKAA FFRNIMNIID 300
LVAIFPYFIT LGTELVQRHE QQSVSGGSGQ NGQQAMSLAI LRVIRLVRVF RIFKLSRHSK 360
GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD DVDSLFPSIP DAFWWAVVTM 420
TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE QEEQGQYTHV 480
TCGQPTPDLK ATDNGLGKPD FAEASRERRP SYLPTPHRAY AEKRMLTEV 529 |
Gene Ontology | GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome. GO:0051260; P:protein homooligomerization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |