UniProt Accession

 DCC1_HUMAN; Q9BVC3; Q969N5 

Genbank Protein ID

 AY358866; AK054585; BC001316; BC001531 

Genbank Nucleotide ID

 AAQ89225.1; BAB70767.1; AAH01316.1; AAH01531.1 

Protein Name

 Sister chromatid cohesion protein DCC1 

Protein Synonyms/Alias

 Defective in sister chromatid cohesion protein 1 homolog 

Gene Name

 DSCC1 

Gene Synonyms/Alias

 DCC1; UNQ9337/PRO34008 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
68	SLVIRGDKDEQAVLC	ubiquitination	[1]
79	AVLCSKDKTYDLKIA	ubiquitination	[1]
84	KDKTYDLKIADTSNM	ubiquitination	[1]
99	LLFIPGCKTPDQLKK	ubiquitination	[1]
154	YEGPDSQKEKDSNSS	ubiquitination	[2]
156	GPDSQKEKDSNSSKY	ubiquitination	[1]
162	EKDSNSSKYTTEDLL	ubiquitination	[1]
247	EMIEHCLKCYGKKYV	ubiquitination	[3]
347	SLFSLREKWTEEDIA	ubiquitination	[1]
364	IQDLCGEKQTIGALL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. 

Sequence Annotation

  

Keyword

 Cell cycle; Complete proteome; DNA replication; DNA-binding; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IDA:UniProtKB.
 GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0034088; P:maintenance of mitotic sister chromatid cohesion; IMP:UniProtKB.
 GO:0034421; P:post-translational protein acetylation; IMP:UniProtKB.
 GO:0006275; P:regulation of DNA replication; IMP:UniProtKB. 

Interpro

 IPR019128; Sister_chromatid_cohesion_Dcc1. 

Pfam

 PF09724; DUF2036 

SMART

  

PROSITE

  

PRINTS