CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040078
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myc proto-oncogene protein 
Protein Synonyms/Alias
  
Gene Name
 Myc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
163AAKLVSEKLASYQAAacetylation[1, 2, 3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 453 AA 
Protein Sequence
LDFLWALETP TATTMPLNVN FTNRNYDLDY DSVQPYFICD EEENFYHQQQ QSELQPPAPS 60
EDIWKKFELL PTPPLSPSRR SGLCSPSYVA VATSFSPRED DDGGGGNFST ADQLEMMTEL 120
LGGDMVNQSF ICDPDDETFI KNIIIQDCMW SGFSAAAKLV SEKLASYQAA RKDSTSLSPA 180
RGHSVCSTSS LYLQDLTAAA SECIDPSVVF PYPLNDSSSP KSCTSSDSTA FSPSSDSLLS 240
SESSPRASPE PLVLHEETPP TTSSDSEEEQ EDEEEIDVVS VEKRQTPAKR SESGSSPSRG 300
HSKPPHSPLV LKRCHVSTHQ HNYAAPPSTR KDYPAAKRAK LDSGRVLKQI SNNRKCSSPR 360
SSDTEENDKR RTHNVLERQR RNELKRSFFA LRDQIPELEN NEKAPKVVIL KKATAYILSI 420
QADEHKLTSE KDLLRKRREQ LKHKLEQLRN SGA 453 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0016604; C:nuclear body; IDA:MGI.
 GO:0005819; C:spindle; IDA:MGI.
 GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
 GO:0001783; P:B cell apoptotic process; IMP:MGI.
 GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:MGI.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:MGI.
 GO:0042474; P:middle ear morphogenesis; IMP:MGI.
 GO:0032091; P:negative regulation of protein binding; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0043473; P:pigmentation; IMP:MGI.
 GO:2001235; P:positive regulation of apoptotic signaling pathway; IDA:MGI.
 GO:0002904; P:positive regulation of B cell apoptotic process; IGI:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0016485; P:protein processing; IMP:MGI.
 GO:0043279; P:response to alkaloid; IMP:MGI.
 GO:0009314; P:response to radiation; IDA:MGI.
 GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
 GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
 GO:0016055; P:Wnt receptor signaling pathway; IDA:MGI. 
Interpro
 IPR011598; bHLH_dom.
 IPR003327; Myc-LZ.
 IPR002418; Tscrpt_reg_Myc.
 IPR012682; Tscrpt_reg_Myc_N. 
Pfam
 PF00010; HLH
 PF02344; Myc-LZ
 PF01056; Myc_N 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS
 PR00044; LEUZIPPRMYC.