UniProt Accession

 CLCA_RAT; P08081 

Genbank Protein ID

 M15882; M19261; M19260 

Genbank Nucleotide ID

 AAA40868.1; AAA40870.1; AAA40869.1 

Protein Name

 Clathrin light chain A 

Protein Synonyms/Alias

 Lca 

Gene Name

 Clta 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
242	RSVLISLKQAPLVH*	acetylation	[1]
242	RSVLISLKQAPLVH*	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. 

Sequence Annotation

 REGION 100 162 Involved in binding clathrin heavy chain.
 MOD_RES 105 105 Phosphoserine (By similarity).
 MOD_RES 206 206 Phosphoserine (By similarity).
 MOD_RES 236 236 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Calcium; Coated pit; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0030132; C:clathrin coat of coated pit; NAS:RGD.
 GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
 GO:0030125; C:clathrin vesicle coat; NAS:RGD.
 GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome.
 GO:0042277; F:peptide binding; IDA:RGD.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0006897; P:endocytosis; IEP:RGD.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 

Interpro

 IPR000996; Clathrin_L-chain. 

Pfam

 PF01086; Clathrin_lg_ch 

SMART

  

PROSITE

 PS00224; CLATHRIN_LIGHT_CHN_1
 PS00581; CLATHRIN_LIGHT_CHN_2 

PRINTS