UniProt Accession

 FL2D_HUMAN; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2 

Genbank Protein ID

 AF374416; D14661; AK127822; AL135914; AL135914; CH471051; CH471051; CH471051; BC000383; BC004432; BC069192; AJ276706; AL583911 

Genbank Nucleotide ID

 AAK54764.1; BAA03495.1; BAG54579.1; CAI21848.1; CAI21849.1; EAW47622.1; EAW47624.1; EAW47625.1; AAH00383.1; AAH04432.1; AAH69192.1; CAC10188.1; CAC29495.1 

Protein Name

 Pre-mRNA-splicing regulator WTAP 

Protein Synonyms/Alias

 Female-lethal(2)D homolog; hFL(2)D; WT1-associated protein; Wilms tumor 1-associating protein 

Gene Name

 WTAP 

Gene Synonyms/Alias

 KIAA0105 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
146	QNELSAWKFTPDR**	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 305 305 Phosphoserine.
 MOD_RES 306 306 Phosphoserine.
 MOD_RES 388 388 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

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