Tag | Content |
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CPLM ID | CPLM-001350 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Electrogenic sodium bicarbonate cotransporter 1 |
Protein Synonyms/Alias | Sodium bicarbonate cotransporter; Na(+)/HCO3(-) cotransporter; Solute carrier family 4 member 4 |
Gene Name | Slc4a4 |
Gene Synonyms/Alias | Nbc1; Nbce1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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67 | ISENYSDKSDVENAD | ubiquitination | [1] | 137 | RWIKFEEKVEQGGER | ubiquitination | [1] | 167 | ELRTCMEKGSIMLDR | ubiquitination | [1] | 197 | QIETGLLKPDLKDKV | ubiquitination | [1] | 203 | LKPDLKDKVTYTLLR | ubiquitination | [1] | 229 | RSLADIGKTVSSASR | ubiquitination | [1] | 264 | SLNDISDKPEKDQLK | ubiquitination | [1] | 267 | DISDKPEKDQLKNKF | ubiquitination | [1] | 331 | LFILLGPKGKAKSYH | ubiquitination | [1] | 359 | VFHDIAYKAKDRHDL | ubiquitination | [1] | 395 | TIRIEPPKSLPSSDK | ubiquitination | [1] | 404 | LPSSDKRKNMYSGGE | ubiquitination | [1] | 448 | RFCGGLIKDIKRKAP | ubiquitination | [1] | 934 | KLLLMPLKHQPDFIY | ubiquitination | [1] | 1046 | SEKVPSIKIPMDIME | ubiquitination | [1] | 1062 | QPFLSDNKPLDRERS | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. |
Sequence Annotation | REGION 748 779 Interaction with CA4 (By similarity). REGION 1002 1004 CA2-binding (By similarity). REGION 1030 1033 CA2-binding (By similarity). REGION 1057 1059 Required for basolateral targeting (By MOD_RES 30 30 Phosphotyrosine. MOD_RES 254 254 Phosphothreonine. MOD_RES 255 255 Phosphoserine. MOD_RES 257 257 Phosphoserine. MOD_RES 262 262 Phosphoserine. MOD_RES 1026 1026 Phosphoserine; by PKA (By similarity). MOD_RES 1029 1029 Phosphoserine. MOD_RES 1034 1034 Phosphoserine. CARBOHYD 641 641 N-linked (GlcNAc...) (By similarity). CARBOHYD 661 661 N-linked (GlcNAc...) (By similarity). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1079 AA |
Protein Sequence | MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKAG HKEKKEKERI 60 SENYSDKSDV ENADESSSSI LKPLISPAAE RIRFILGEED DSPAPPQLFT ELDELLAVDG 120 QEMEWKETAR WIKFEEKVEQ GGERWSKPHV ATLSLHSLFE LRTCMEKGSI MLDREASSLP 180 QLVEMIADHQ IETGLLKPDL KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFSN 240 PDNGSPAMTH RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI 300 AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD EVFHDIAYKA 360 KDRHDLIAGI DEFLDEVIVL PPGEWDPTIR IEPPKSLPSS DKRKNMYSGG ENVQMNGDTP 420 HDGGHGGGGH GDCEELQRTG RFCGGLIKDI KRKAPFFASD FYDALNIQAL SAILFIYLAT 480 VTNAITFGGL LGDATDNMQG VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF 540 NFSKDHNFDY LEFRLWIGLW SAFMCLVLVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA 600 FKKMIKLADY YPINSDFKVG YNTHFSCACL PPDPVNLSVS NDTTLAPEDL PTISSTDMYH 660 NVTFDWAYLS KKECVKYGGK LVGNNCDFVP DITLMSFILF LGTYTSSMAM KKFKTSRYFP 720 TTARKLISDF AIILSILIFC VIDALVGVDT PKLIVPSEFK PTSPNRGWFV PPFGGNPWWV 780 CLAAAIPALL VTILIFMDQQ ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VVCSFMALPW 840 YVAATVISIA HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI 900 PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV HLFTFLQVLC 960 LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS FLDDVIPEKD KKKKEDEKKK 1020 KKKKGSLDSD NDDSDCPYSE KVPSIKIPMD IMEQQPFLSD NKPLDRERSS TFLERHTSC 1079 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; TAS:MGI. GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. GO:0008510; F:sodium:bicarbonate symporter activity; ISS:MGI. GO:0006885; P:regulation of pH; TAS:MGI. |
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