UniProt Accession

 CYC_MOUSE; P62897; P00009; Q8C2S2 

Genbank Protein ID

 X01756; AK088098; BC034363 

Genbank Nucleotide ID

 CAA25899.1; BAC40143.1; AAH34363.1 

Protein Name

 Cytochrome c, somatic 

Protein Synonyms/Alias

  

Gene Name

 Cycs 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MGDVEKGKKIFVQ	acetylation	[1]
87	KMIFAGIKKKGERAD	acetylation	[2]
100	ADLIAYLKKATNE**	acetylation	[2]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. 

Sequence Annotation

 METAL 19 19 Iron (heme axial ligand).
 METAL 81 81 Iron (heme axial ligand).
 BINDING 15 15 Heme (covalent).
 BINDING 18 18 Heme (covalent).
 MOD_RES 2 2 N-acetylglycine.
 MOD_RES 49 49 Phosphotyrosine (By similarity).
 MOD_RES 98 98 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Electron transport; Heme; Iron; Metal-binding; Mitochondrion; Phosphoprotein; Reference proteome; Respiratory chain; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 105 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR002327; Cyt_c_1A/1B.
 IPR009056; Cyt_c_dom.
 IPR003088; Cyt_c_I. 

Pfam

 PF00034; Cytochrom_C 

SMART

  

PROSITE

 PS51007; CYTC 

PRINTS

 PR00604; CYTCHRMECIAB.