CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014190
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial 
Protein Synonyms/Alias
 3-oxoacid CoA-transferase 2A; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; SCOT-t1 
Gene Name
 Oxct2a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
41TTRCGKVKFYTDPVKacetylation[1]
48KFYTDPVKAVEGIKDacetylation[1]
83ALKTKGVKDLKIISSacetylation[1]
106LGILLASKQVRRVVCacetylation[1]
211RADFALIKGWKADRSacetylation[1]
214FALIKGWKADRSGNVacetylation[1]
271IYVKRVIKGPRFEKRacetylation[1]
312KRAALEFKDGMYANLacetylation[1]
355LGPFPLKKEVDPDIIacetylation[1]
419MVPGKKVKGMGGAMDacetylation[1]
431AMDLVSSKKTKVVVTacetylation[1]
480VFEVDRSKGLKLVELacetylation[1]
483VDRSKGLKLVELWEGacetylation[1]
517LKPMQQIKSDA****acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa (By similarity). 
Sequence Annotation
 ACT_SITE 342 342 Acyl-thioester intermediate (By  
Keyword
 Complete proteome; Mitochondrion; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MAALRLLAWA FSRRVSAHRP QPTLPHHLIR HYPTTRCGKV KFYTDPVKAV EGIKDGASVM 60
LGGFGLCGIP ENLIGALKTK GVKDLKIISS NVGVDDFGLG ILLASKQVRR VVCSYLGENK 120
LCEQLYLAGK LELEMTPQGT LAERIRAGGT GVPAFYTPTG YGTQVQEGGV PIRYSPEGHL 180
ITLSQPREVR EFEGQHHLLE RAIRADFALI KGWKADRSGN VIFRGSARNF NVPMCKAADI 240
SVVEVEEIVD VGTFAPEDIH IPNIYVKRVI KGPRFEKRIE RLTTRDSPPA PGSKDQDPKR 300
TRIIKRAALE FKDGMYANLG IGIPVLASNY ISPKMTVYLH SENGILGLGP FPLKKEVDPD 360
IINAGKQTVT VIPGGCFFAS DDSFAMIRGG HIQLTMLGAM QVSKYGDLAN WMVPGKKVKG 420
MGGAMDLVSS KKTKVVVTME HCTKTKQPKI LEKCTMPLTG KSCVDLIITE KAVFEVDRSK 480
GLKLVELWEG SSLDEVKATT GCSFKVCPNL KPMQQIKSDA 520 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:EC.
 GO:0046952; P:ketone body catabolic process; IEA:InterPro. 
Interpro
 IPR012792; 3-oxoacid_CoA-transf_A.
 IPR012791; 3-oxoacid_CoA-transf_B.
 IPR014388; 3-oxoacid_CoA-transferase.
 IPR004165; CoA_trans_fam_I.
 IPR004164; CoA_transf_AS.
 IPR004163; CoA_transf_BS. 
Pfam
 PF01144; CoA_trans 
SMART
 SM00882; CoA_trans 
PROSITE
 PS01273; COA_TRANSF_1
 PS01274; COA_TRANSF_2 
PRINTS